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Iranian Biomedical Journal، جلد ۲۲، شماره ۲، صفحات ۷۸-۸۹
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Association between Thrombophilic Genes Polymorphisms and Recurrent Pregnancy Loss Susceptibility in the Iranian Population: a Systematic Review and Meta-Analysis
چکیده انگلیسی مقاله Studies have indicated that thrombophilic genes polymorphisms are associated with recurrent pregnancy loss (RPL) in the Iranian population. We aimed to evaluate the precise association between thrombophilic genes polymorphisms (MTHFR C677T, MTHFR A1298C, Prothrombin G20210A, FVL G1691A, and PAI-1 4G/5G) and RPL risk in the Iranian population. PubMed, Web of Science, Google Scholar, and ISC were searched for eligible articles published up to April 1, 2017. In total, 37 case-control studies in 18 relevant publications were selected: 1,199, 1,194, 630, 830, and 955 RPL cases and 1,079, 1079, 594, 794, and 499 controls for MTHFR C677T, MTHFR A1298C,Prothrombin G20210A, FVL G1691A, and PAI-1 4G/5G, respectively. The results indicated a significant increased risk of RPL in all genetic models in the population. Also, Prothrombin G20210A and FVL G1691A as well as PAI-1 4G/5G  polymorphisms were associated with RPL risk in the Iranian population. Hence, thrombophilic genes polymorphisms are associated with an increased RPL risk in the Iranian population.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله مهدیه کمالی | mahdieh kamali
department of perinatology, school of medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

صدیقه حنطوش زاده | sedigheh hantoushzadeh
department of perinatology, school of medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

صدیقه برنا | sedigheh borna
maternal-fetal and neonatal research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

حسین نعمت زاده | hossein neamatzadeh
department of medical genetics, shahid sadoughi university of medical sciences, yazd, iran


مهتا مظاهری | mahta mazaheri
department of medical genetics, shahid sadoughi university of medical sciences, yazd, iran


محمود نوری شادکام | mahmood noori shadkam
mother and newborn health research center, shahid sadoughi university of medical sciences, yazd, iran


فاطمه حقیقی | fatemeh haghighi
department of gynecology and obstetrics, shahid sadoughi university of medical sciences, yazd, iran
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-680&slc_lang=en&sid=en
فایل مقاله دریافت فایل مقاله
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Molecular Genetics & Genomics
نوع مقاله منتشر شده مقاله کامل
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