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Physiology and Pharmacology، جلد ۱۸، شماره ۴، صفحات ۴۳۷-۴۴۴
عنوان فارسی اثر بلوکر گیرنده Mas (A۷۷۹) و فشار پرفیوژن کلیوی بر غلظت نیتریت در غیاب رسپتورهای۱&۲ آنژیوتانسینII در رت های نر و ماده
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The effects of Mas receptor antagonist (A779) and renal perfusion pressure on serum nitrite concentration in male and female rats when angiotensin II receptors 1 & 2 were blocked
چکیده انگلیسی مقاله Introduction: Renin angiotensin system has an important role in blood pressure and renal functions. Active angiotensin-converting enzyme 2 converts angiotensin I into angiotensin-(1-7) which is a vasodilator hormone and interacts with nitric oxide changes as well as other angiotensin II receptors. In this study we evaluated the role of Mas receptor antagonist (A779) and renal perfusion pressure (RPP) on serum nitric oxide metabolite (nitrite) concentration when angiotensin II receptors (AT1R & AT2R) were blocked. Methods: After angiotensin II receptors blockage in anesthetized male and female rats, RPP was maintained at two levels 80 & 100 mmHg by occluder around aorta above the renal arteries, and the effects of placebo and A779 on concentration of serum nitrite level were studied. Results: The results showed that when angiotensin II receptors were blocked, the serum level of nitrite in both sexes, was not dependent on angiotensin-(1-7) receptor and did not change statistically, but by increasing renal perfusion pressure and in the presence of angiotensin-(1-7) receptor the serum level of nitrite increased significantly (p< 0.05) in male rats but not in female rats. Conclusion: Using angiotensin II receptors blockades and by increase of RPP, the serum level of nitrite is sexrelated. This study showed the importance of Mas receptor in male sex when AT1R & AT2R were blocked.
کلیدواژه‌های انگلیسی مقاله Angiotensin (1-7),Mas receptor, Angiotensin II receptors, NO
نویسندگان مقاله اعظم منصوری | azam mansoori
water amp; electrolytes research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

شهربانو عریان | shahrebanoo oryan
dept. of biology, university of kharazmi, tehran, iran


مهدی نعمت بخش | mehdi nematbakhsh
water amp; electrolytes research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://phypha.ir/ppj/browse.php?a_code=A-10-788-1&slc_lang=en&sid=en
فایل مقاله دریافت فایل مقاله
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده Kidney
نوع مقاله منتشر شده Original Research
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