این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Physiology and Pharmacology، جلد ۹، شماره ۲، صفحات ۱۰۷-۱۱۴
عنوان فارسی The Role of Ca۲+ and K+ channels in regulation the pattern of spontaneous activity in cerebellar Purkinje cells.
چکیده فارسی مقاله The Role of Ca2+ and K+ channels in regulation the pattern of spontaneous activityin cerebellar Purkinje cells.H Haghdoost Yazdi, M Janahmadi and G BehzadiDept. Physiology and Neuroscience Research Center, School of Medicine,Shaheed Beheshti Univ. Med. Sci., Tehran, Iran.Abstract:The cerebellum is responsible for coordination of movement and maintenance of balance. Purkinje cells (PCs) areprinciple neurons of anatomically well defined cerebellar modules and it is proposed that coordination of movementis achieved by encoding timing signals in the rate of firing and pattern of activity these cells. Understanding ofcerebellar timing requires an appreciation of the intrinsic firing behavior of PCs.In order to determine how changes in membrane biophysics including Ca2+ and K+ channels activity influencethe electrical activity of Purkinje neurons, intracellular recording from acutely prepared cerebellar slices wasperformed. PCs fired spontaneously bursts of calcium or sodium-calcium spikes which were separated by1Physiology and PharmacologyKeywords: Purkinje Neurons, Firing Pattern, Brain Slices, Intracellular Recording, Apamin, DTXquiescent- interburst periods. They also showed long lasting bursts and long silence periods. Cadmium, a wildrange of Ca2+ channels blocker, resulted in an elimination of calcium spikes while left the sodium action potentialintact. Blockade potassium channels by 4-AP and TEA improved the spontaneous activity and limited silenceperiod. 4-AP also prolonged the burst and interburst period and decreased the firing frequency. On the otherhand, apamin, a neurotoxin from bee venom, known to selectively block small conductance of calcium activatedpotassium channels (SK), and α-dendrotoxin (DTX), specific blocker of Kv1 channels, shortened the burstand interburst duration. DTX and apamin also increased the frequency of burst occurrence and DTX decreasesintraburst frequency.In conclusion, with the data presented it is fair to state that intrinsic membrane properties including K+ channelsactivity, seem to play important roles in the formation of firing patterns in Purkinje neurons.
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی
چکیده انگلیسی مقاله
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله
نشانی اینترنتی http://phypha.ir/ppj/browse.php?a_code=A-10-25-1&slc_lang=en&sid=en
فایل مقاله دریافت فایل مقاله
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Research
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات