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Physiology and Pharmacology، جلد ۹، شماره ۲، صفحات ۱۲۱-۱۲۶
عنوان فارسی Comparison of effects of two anesthetic drugs, urethan and ketamine-rompane on basal, histamine-, carbachol-, and pentagastrin-induced gastric acid secretion in male rats
چکیده فارسی مقاله A Ghanbari and A EliassiDept. Physiology and Neuroscience Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.Abstract:Urethan inhibits basal and histamine-stimulated gastric acid secretion (GAS). Also, ether induces similar effect on thebasal and stimulated acid output. Anesthetized animals are often used in studies of regulatory mechanisms of GAS.Therefore, considering the effect of anesthetic drugs on the acid secretion is very important. The aim of this study is tocompare the effects of anesthetic drugs, ketamine-rompane and urethan, on basal and stimulated gastric acid secretion.For all gastric sampling, animals were anesthetized and a polyethylene tube was introduced into the stomachthrough esophagus and a cannula was inserted into the pyloroduodenal junction and passed up into the stomachfor saline injection and aspiration of gastric secretion, respectively. Our experiments revealed that basal acidoutput significantly reduced in rats given urethan compared to ketamine-rompane treated rats (P < 0.001). Also,intravenous infusion of histamine (0.5 mg/100 g/hr) and pentagastrin (2 microgram/100 g/hr) induced markedincrease in acid secretion with a peak response that was started from min 30 and continued up to the end ofexperiments (min 90). Intravenous infusion of carbachol (1 microgram/100 g/ hr) induces marked increase in acidsecretion with a peak response that was started from min 10 and continued up to min 90. In all groups, urethancompared with ketamine-rompane significantly reduced the stimulated gastric acid secretion.Keywords: Pentagasterine.Urethan, Ketamine, Anesthetized rat(s), Stimulated gastric acid secretion, Carbachol, Histamine,
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نشانی اینترنتی http://phypha.ir/ppj/browse.php?a_code=A-10-68-1&slc_lang=en&sid=en
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