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Physiology and Pharmacology، جلد ۹، شماره ۲، صفحات ۱۵۹-۱۶۲
عنوان فارسی Effect of finastride, an inhibitor of ۵ α-reductase, on physical dependence induced by chronic administration of morphine in male rats
چکیده فارسی مقاله J Verdi and A AhmadianiDept. Pharmacology and Neuroscience Research Center, Shaheed Beheshti Univ. Med. Sci.,Tehran, Iran.Abstract:Tolerance and dependence are two main problems which have limited morphine administration as an analgesicdrug. Following acute and chronic administration of morphine changes in the level of sex steroids and the activityof calcium channels are reported. The enzyme 5 α-reductase plays a pivotal role in the conversion of testosteroneto dehydrotestosterone and therefore reduces the testosterone levels. In this investigation, we tried to study theeffects of acute and chronic administration of finastride (inhibitor of 5 α-reductase) on morphine dependence inthe male rats.Morphine dependency was induced by the intraperitoneal (i.p.) injection of morphine for 4 days (20, 30, 40 and40 mg/kg respectively at days 1-4). Physical dependence to morphine was observed following administration ofnaloxone (2 mg/kg-i.p., day 5).Acute administration of finastride at 5th day (5 mg/kg-i.p., twice with 2 hours interval), decreased allwithdrawal signs significantly, while the administration the vehicle, caster oil, did not. Chronic administrationof finastride prior to daily administration of morphine during days 1-4 significantly decreased all withdrawalsigns at the day 5. This finding indicates that inhibition of testosterone metabolism in the CNS usingfinastride may be able to modulate the withdrawal sings expression and prevents the development of physicaldependence.Keywords: 5 alpha-reductase, Finastride, Dependence, Morphine
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عنوان انگلیسی
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نشانی اینترنتی http://phypha.ir/ppj/browse.php?a_code=A-10-71-1&slc_lang=en&sid=en
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نوع مقاله منتشر شده Original Research
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