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Journal of Arthropod-Borne Diseases، جلد ۱۱، شماره ۴، صفحات ۴۹۷-۵۰۳
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عنوان انگلیسی The Effects of Isolated Fractions of Mesobuthus eupeus Scorpion Venom on Humoral Immune Response
چکیده انگلیسی مقاله Background: Many elements such as immunosuppressive, chemotactic and anti-inflammatory peptide that could effect on human and animals physiologic system were determined in venom. This study evaluated the use of Meso­buthus eupeus scorpion venom fractions as an immunomodulator. Methods: The venom fractions collected from Khuzestan Province in South West of Iran were purified by ion ex­change chromatography. Elution of the bounded elements was done by using a linear gradient of sodium chloride (0.1, 0.25, 0.5, 0.75, 1, 1.25, 1.5 and 2 molar). The fractions were analyzed by Bradford spectrophotometric and SDS-PAGE method. After treatments of chicken with venom fractions and sheep red blood cell (SRBC), direct hae­magglutination test in microtiter plate was used for the determination of the chicken SRBC antibody titer. Results: The fraction released by NaCl 1.25M had the highest protein concentration. The highest and lowest anti­body titer was determined at the fifth (NaCl 0.75 molar) and seventh fraction (NaCl 1.25 molar), respectively. Conclusion: Different protein profile of isolated fractions, were associated with various effect on immune response. Both enhancing and suppressing of the chicken humoral immune response to SRBC were observed after M. eupeus faction’s venom treatment. It is due to biological functions of venom components. Purification of these elements would provide the new agents for immune responses manipulation.
کلیدواژه‌های انگلیسی مقاله Venom, Mesobuthus eupeus, Immune response
نویسندگان مقاله محمد خسروی | mohammad khosravi
department of clinical sciences, faculty of veterinary medicine, shahid chamran university of ah-vaz, ahvaz, iran

سازمان اصلی تایید شده: دانشگاه شهید چمران (Shahid chamran university)

منصور میاحی | mansour mayahi
student of veterinary medicine, faculty of veterinary medicine, shahid chamran university of ahvaz, ahvaz, iran

سازمان اصلی تایید شده: دانشگاه شهید چمران (Shahid chamran university)

فرنوش کاویانی | farnoosh kaviani
razi reference laboratory of scorpion research, razi vaccine and serum research institute, alborz, iran

سازمان اصلی تایید شده: موسسه تحقیقات واکسن و سرم سازی رازی (Razi vaccine and serum research institute)

محمد نعمتی | mohammad nemati


نشانی اینترنتی http://jad.tums.ac.ir/index.php/jad/article/view/774
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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