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Iranian Journal of Kidney Diseases، جلد ۱۰، شماره ۱، صفحات ۳۶-۰
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عنوان انگلیسی Absolute and Relative Carnitine Deficiency in Patients on Hemodialysis and Peritoneal Dialysis
چکیده انگلیسی مقاله Introduction. Carnitine deficiency is commonly seen in dialysis patients. This study assessed the association dialysis and pediatric patients' characteristics with plasma carnitines levels. Materials and Methods. Plasma carnitine concentrations were measured by tandem mass spectrometry in 46 children on hemodialysis or peritoneal dialysis. The total carnitine, free carnitine (FC), and L-acyl carnitine (AC) levels of 40 µmol/L and less, less than 7 µmol/L, and less than 15 µmol/L were defined low, respectively. An FC less than 20 µmol/L and an AC/FC ratio greater than 0.4 were considered as absolute and relative carnitine deficiencies. The correlation between carnitines levels and AC/FC ratio and age, duration of dialysis, characteristics of dialysis, and blood urea nitrogen and serum albumin concentrations were assessed. Results. Absolute carnitine deficiency, low total carnitine, and low AC concentrations were found in 66.7%, 82.6%, and 51% of the patients, respectively. All of the patients had relative carnitine deficiency. Carnitine measurements were not significantly different between the hemodialysis and peritoneal dialysis groups. More severe relative carnitine deficiency was found in those with lower blood urea nitrogen levels and those on peritoneal dialysis. No linear correlation was found between carnitine levels and age, duration of dialysis, characteristics of dialysis, serum albumin level, or blood urea nitrogen level. Conclusions. Absolute and relative carnitine deficiencies are common among children on dialysis. Patients with lower blood urea nitrogen levels and peritoneal dialysis patients are more prone to severe relative carnitine deficiency.
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نویسندگان مقاله میترا ناصری | mitra naseri


حسن متقی مقدم شهری | hasan mottaghi moghadam shahri


محسن حری | mohsen horri


محمد اسماعیلی | mohammad esmaeeli


فاطمه قانع شعرباف | fatemeh ghaneh sherbaf


شهره جهانشاهی | shohre jahanshahi


گیتی moeenolroayaa | giti moeenolroayaa


زهرا رسولی | zahra rasoli


فرزانه سالمیان | farzaneh salemian


مریم پور حسن | maryam pour hasan


نشانی اینترنتی http://www.ijkd.org/index.php/ijkd/article/view/2178
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده ORIGINAL | Dialysis
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