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Iranian Journal of Kidney Diseases، جلد ۹، شماره ۲، صفحات ۹۷-۰
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عنوان انگلیسی Vitamin E as Adjuvant Treatment for Urinary Tract Infection in Girls with Acute Pyelonephritis
چکیده انگلیسی مقاله Introduction. Vitamin E is a fat-soluble vitamin that functions as an antioxidant. The aim of this study was to investigate the effects of vitamins E supplementation in combination with antibiotics for the treatment of girls with acute pyelonephritis. Materials and Methods. This double-blinded randomized controlled trial was conducted on 152 girls aged 5 to 12 years with a first acute pyelonephritis episode based on technetium Tc 99m dimercaptosuccinic acid ( 99m Tc-DMSA). They were randomized to receive a 14-day treatment with only antibiotics (control group; n = 76) and 14-day treatment with supplements of vitamin E (intervention group; n = 76) in addition to the antibiotics. Patients' clinical symptoms were monitored for 14 days and urine culture was performed 3 to 4 days and 7 to 10 days after the start of the treatment and its completion, respectively. All of the girls once underwent DMSA scan 4 to 6 months after the treatment. Results. During the follow-up days, the mean frequency of fever ( P = .01), urinary frequency ( P = .001), urgency ( P = .003), dribbling ( P = .001), and urinary incontinence ( P = .006) were significantly lower in the intervention group compared to the control group. There was no significant difference in the results of urine culture 3 to 4 days after the start of treatment ( P = .16) and 7 to 10 days after its termination ( P = .37). There was also no significant difference between the results of DMSA scan 4 to 6 months after the start of treatment ( P = .31). Conclusions. Vitamin E supplementation has a significant effect in ameliorating sign and symptoms of UTI. However, further studies are recommended to confirm these findings.
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نویسندگان مقاله پارسا یوسفی چایجان | parsa yousefichaijan


منیژه کهبازی | manigeh kahbazi


سارا راستی | sara rasti


محمد رفیعی | mohammad rafeie


مجتبی شرفخواه | mojtaba sharafkhah


نشانی اینترنتی http://www.ijkd.org/index.php/ijkd/article/view/1596
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نوع مقاله منتشر شده ORIGINAL | Kidney Diseases
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