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Iranian Journal of Kidney Diseases، جلد ۸، شماره ۳، صفحات ۱۹۴-۰
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عنوان انگلیسی Regulatory Effects of Chronic Low-dose Morphine on Nitric Oxide Level Along With Baroreflex Sensitivity in Two-kidney One-clip Hypertensive Rats
چکیده انگلیسی مقاله Introduction. Opiates are traditionally used for treatment of some acute heart disorders. There are only few reports on the effects of long-term treatment of cardiovascular diseases with morphine. This study aimed to investigate the effects of chronic low-dose morphine use on the cardiovascular system in two-kidney one-clip (2K1C) hypertensive rats. Materials and Methods. Male Wistar rats were divided into two groups as the sham and 2K1C groups and each group was further subdivided into saline and morphine treatment subgroups. Blood pressure, heart rate, plasma rennin activity, serum nitric oxide concentration, and baroreflex sensitivity were measured. Results. Morphine significantly attenuated systolic blood pressure, diastolic blood pressure, and mean arterial pressure in the 2K1C animals. In addition, morphine decreased plasma rennin activity in the 2K1C group. Serum concentrations of nitric oxide were also decreased, and morphine prevented the reduction of nitric oxide. The baroreflex sensitivity was also improved following morphine administration in the 2K1C group. Conclusions. According to the results presented in this study, chronic administration of low-dose morphine reduces regulated hypertension in the 2K1C rats, probably via a nitric oxide-dependent pathway.
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نویسندگان مقاله حسین رضازاده | hossein rezazadeh


محمدامین حسینی کهنویی | mohammadamin hosseini kahnouei


غلامحسین حسن شاهی | gholamhossein hassanshahi


محمد الله توکلی | mohammad allahtavakoli


علی شمسی زاده | ali shamsizadeh


علی روحبخش | ali roohbakhsh


ایمان فاطمی | iman fatemi


محمدرضا زریسفی | mohammadreza zarisfi


علی اصغر پورشانظری | ali asghar pourshanazari


نشانی اینترنتی http://www.ijkd.org/index.php/ijkd/article/view/1149
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده ORIGINAL | Kidney Diseases
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