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Iranian Journal of Kidney Diseases، جلد ۶، شماره ۱، صفحات ۵۶-۰
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عنوان انگلیسی Chemokine Receptor 2-V64I and Chemokine Receptor 5-Delta32 Polymorphisms and Clinical Risk Factors of Delayed Graft Function and Acute Rejection in Kidney Transplantation
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Calibri","sans-serif"; mso-fareast-font-family:Calibri; mso-bidi-font-family:Arial;} Introduction. Chemokines and chemokine receptors have a pivotal role in immunity and inflammation. We aimed to evaluate their role in kidney transplant rejection. Materials and Methods. The association of chemokine (C-C motif) receptor 2 ( CCR2 )- V64I and CCR5-Delta32 gene polymorphisms with acute rejection (AR) and delayed graft function (DGF) were examined in 100 donor-recipient pairs. The CCR2-V64I and CCR5-Delta32 alleles were determined using polymerase chain reaction and polymerase chain reaction-restriction fragment length polymorphism, respectively. Results. No associations were found between donors or recipients' CCR2-V64I and CCR5-Delta32 gene polymorphisms and AR or DGF. Of the characteristics of the donors, recipients, and transplantation, glomerulonephritis as a cause of kidney failure in the recipients was weakly associated with AR (relative risk, 6.1; 95% confidence interval, 0.8 to 46.0; P = .07). Transplantation of kidney from females to males was weakly associated with DGF (relative risk, 5.5; 95% confidence interval, 0.9 to 33.0; P = .06). There was a significant association between AR, but not DGF, and graft loss in the patients (relative risk, 28.6; 95% confidence interval, 1.7 to 487.0; P = .03). Conclusions. Our study failed to suggest CCR2-V64I or CCR5-Delta32 gene polymorphisms as risk factors for AR and DGF in kidney transplantation. Sex-matching between donors and recipients should be considered for living donor kidney transplantation.
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نویسندگان مقاله جلال آزمندیان | jalal azmandian


علی ماندگاری | ali mandegary


آزاده صابر | azadeh saber


مریم ترشابی | maryam torshabi


عباس اطمینان | abbas etminan


محمدرضا عبادزاده | mohammad reza ebadzadeh


فرامرز فاضلی | faramarz fazeli


سمانه سلیمانی | samaneh soleymani


عاطفه تقی پور | atefeh taghipour


محمد علی کریمی | mohammad ali karimi


نشانی اینترنتی http://www.ijkd.org/index.php/ijkd/article/view/607
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده ORIGINAL | Transplantation
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