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Iranian Journal of Kidney Diseases، جلد ۵، شماره ۶، صفحات ۴۱۰-۰
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عنوان انگلیسی Effect of Vitamin C on Parathyroid Hormone in Hemodialysis Patients With Mild to Moderate Secondary Hyperparathyroidism
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman","serif";} Introduction. In end-stage renal disease, there is a high incidence of secondary hyperparathyroidism. It is proposed that increasing vitamin C levels by dietary supplementation results in a decrease of parathyroid hormone (PTH) in vitamin C-deficient hemodialysis patients with secondary hyperparathyroidism. The aim of this study was the evaluation of vitamin C administration for reduction of serum PTH level in hemodialysis patients. Materials and Methods. Twenty-one hemodialysis patients with serum PTH levels less than 550 pg/mL (but more than 200 pg/mL) were administered intravenous vitamin C, 200 mg, 3 times per week for 3 months. Blood samples for measurement of PTH were obtained at the beginning of the hemodialysis session every month for three months. Results. The mean level of serum biointact PTH was 333.3 ± 141.3 pg/mL (reference range, 7 pg/mL to 82 pg/mL) at baseline, and it decreased to 256.5 ± 137.2 pg/mL at 1 month ( P = .03). The mean PTH level was also lower than the baseline value at 2 months (260.1 ± 123.2 pg/mL, P = .03), while it increased to 328.9 ± 176.0 pg/mL at 3 months, which was still slightly lower than the baseline level ( P = .13). In 15 patients (71.4%), serum levels of PTH were lower than the baseline at months 1 to 2, while in the remaining 6 (28.6%), it was higher than the baseline value. At 3 months, 5 of the 15 patients with lower PTH levels up to the 3rd month experienced an increase in these levels again. Conclusions. Administration of intravenous vitamin C in hemodialysis patients noticeably decreased level of PTH, but its effect gradually diminished.
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نویسندگان مقاله هوشنگ سندگل | houshang sanadgol


مهتاب بیانی | mahtab bayani


مهدی محمدی | mahdi mohammadi


بکتاش بیانی | baktash bayani


محمد علی مشهدی | mohammad ali mashhadi


نشانی اینترنتی http://www.ijkd.org/index.php/ijkd/article/view/504
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده ORIGINAL | Dialysis
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