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Iranian Journal of Kidney Diseases، جلد ۴، شماره ۴، صفحات ۲۸۵-۰
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عنوان انگلیسی Protective Effect of Grape Seed Extract on Gentamicin-Induced Acute Kidney Injury
چکیده انگلیسی مقاله Introduction. This study was designed to determine the protective effect of red grape seed extract (RGSE) on gentamicin-induced nephrotoxicity in rats. Materials and Methods. Thirty male Wistar rats were divided into 3 groups to receive RGSE, for 60 days followed by intraperitoneal injection of saline solution (as placebo) for 8 days (group 1); RGSE followed by gentamicin for 8 days (group 2); and gentamicin without pre-medication of RGSE (group 3). Oral RGSE, 40 mg/kg/d, and intraperitoneal injection of gentamicin, 100 mg/kg/d, were administered in these groups of rats. Blood and urine samples were collected on days 0 and 68 of the study. Then, the kidneys were removed for pathologic examination. Results. On day 68, serum creatinine and blood urea nitrogen concentrations were highest in group 3, which was significantly higher than in group 1 (P = .001 and P = .004, respectively), while slightly higher than in group 2 (P = .30 and P = .50, respectively). Fractional excretion of sodium was not significantly different between the three groups. Histopathological evaluation showed that rats in group 3 had significantly higher degrees of severe acute tubular necrosis and interstitial mononuclear cell infiltration than the rats in groups 1 and 2 (P Conclusions. This animal study suggests that pretreatment with RGSE protects against gentamicin-induced acute kidney injury as evident on tissue histology. However, this was not accompanied with significant improvement in biochemical markers of kidney injury.
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نویسندگان مقاله جاوید صفا | javid safa


حسن ارگانی | hassan argani


بهار باستانی | bahar bastani


نریمان نظامی | nariman nezami


بابک رحیمی اردبیلی | babak rahimi ardebili


امیر قربانی حق جو | amir ghorbanihaghjo


حسن kalagheichi | hassan kalagheichi


اکبر amirfirouzi | akbar amirfirouzi


مهران مسگری | mehran mesgari


جعفر سلیمانی راد | jafar soleimany rad


نشانی اینترنتی http://www.ijkd.org/index.php/ijkd/article/view/227
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نوع مقاله منتشر شده ORIGINAL | Kidney Diseases
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