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Iranian Journal of Pathology، جلد ۱۲، شماره ۴، صفحات ۳۶۲-۳۷۰
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عنوان انگلیسی Dose-Dependent Effects of Common Antibiotics Used to Treat Staphylococcus aureus on Biofilm Formation
چکیده انگلیسی مقاله Background & Objective: Staphylococcus aureus, especially methicillin-resistant S. aureus (MRSA), represent serious nosocomial and community infections. Biofilm formation as an important virulence factor may be affected by sub-inhibitory levels of antibiotics. Few studies examined the effects of all therapeutic antimicrobial agents on clinical S.aureus. The current study aimed at observing the inducing and reducing effects of antibiotics, commonly used to treat staphylococcal infections on the production of staphylococcal biofilm. Methods: Four MRSA (1ATCC and 3 clinical) and 1 methicillin-susceptible Staphylococcus aureus (MSSA) strains with biofilm forming ability, evaluated by the Congo red agar (CRA) plate test, were employed. Biofilm formation was measured by crystal violet microtiter plate assay. Cefazolin, rifampicin, vancomycin, oxacillin, clindamycin, cotrimoxazole, minocycline, linezolid, azithromycin, and clarithromycin were added to wells ranging from 0.06to 128 µg/mL (1× to 1/1024 MIC dependent on the MIC value of each strain). Results: The current study showed that azithromycin and vancomycin had a significant inducing effect on biofilm formation. In contrast, linezolid, cefazolin, and clarithromycin, and in the second place, clindamycin and minocycline could inhibit the level of biofilm production in the sub-minimal inhibitory concentrations. Conclusion: The findings demonstrated that the biofilm formation as an important virulence factor may be affected by the subinhibitory levels of antibiotics.
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نویسندگان مقاله علی مجیدپور |
antimicrobial resistance research center, rasoul-e-akram hospital, iran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

مستانه افشار |
antimicrobial resistance research center, rasoul-e-akram hospital, iran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

سارا فتحی زاده | fathi zadeh
antimicrobial resistance research center, rasoul-e-akram hospital, iran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

محمد رهبر |
1. antimicrobial resistance research center, rasoul-e-akram hospital, iran university of medical sciences, tehran, iran 2. department of microbiology, reference health laboratories research centre, ministry of health and medical education, tehran, iran
سازمان اصلی تایید شده: وزارت بهداشت درمان و آموزش پزشکی (Ministry of health and medical education)

سمیرا رسولی کوهی | rasouli koohi
antimicrobial resistance research center, rasoul-e-akram hospital, iran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

مرجان حیدرزاده |
department of biology, faculty of food industry and agriculture standard research institute sri ,karaj, iran

لیلا اربابی |
antimicrobial resistance research center, rasoul-e-akram hospital, iran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

مریم ادبی |
antimicrobial resistance research center, rasoul-e-akram hospital, iran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

نشانی اینترنتی http://ijp.iranpath.org/article_27993_ab19e74054c35d877682f93b28cf4e8c.pdf
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