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Iranian Journal of Kidney Diseases، جلد ۴، شماره ۲، صفحات ۱۵۳-۰
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عنوان انگلیسی Cyclosporine Trough Levels and Its Side Effects in Kidney Transplant Recipients
چکیده انگلیسی مقاله Introduction. Cyclosporine is the backbone of immunosuppression in kidney transplantation. However, it is associated with side effects, some of which are dose-dependent. We evaluated association between cyclosporine trough level and its side effects. Materials and Methods. In 50 kidney transplant recipients, serum cyclosporine level, fasting blood glucose, and serum creatinine were measured 7 times during first 6 months after transplantation. The participants were also assessed for blood pressure, hand tremor, and headache at each visit. The relationship between cyclosporine trough level and hypertension, hyperglycemia, hand tremor, and headache were evaluated. Results. There were no significant relationship between cyclosporine levels and allograft function. Except at the second week and sixth month, there were no significant differences between drug doses in various serum cyclosporine trough level groups. At the second week, the mean drug dose in patients with cyclosporine trough levels less than the target therapeutic level was 279.16 ± 56.23 mg/d, while in the patients with cyclosporine levels higher than the therapeutic level, its dose was 302.08 ± 66.61 mg/d (P Conclusions. We demonstrated cyclosporine trough level had no direct relation with drug side effects and it is not a suitable measure for assessment of drug side effects.
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نویسندگان مقاله مریم حامی | maryam hami


محمد جواد مجاهدی | mohammad javad mojahedi


مسیح نقیبی | masih naghibi


محمد تقی شاکری | mohammad taghi shakeri


فرزانه شریفی پور | farzaneh sharifipour


نشانی اینترنتی http://www.ijkd.org/index.php/ijkd/article/view/211
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده ORIGINAL | Transplantation
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