این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Kidney Diseases، جلد ۳، شماره ۴، صفحات ۲۱۰-۰
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عنوان انگلیسی Management and Outcome of Steroid-Resistant Nephrotic Syndrome in Children
چکیده انگلیسی مقاله Introduction. Steroid-resistant nephrotic syndrome (SRNS) is uncommon in children, but often leads to ESRD. We report our experience with SRNS and its treatments and outcomes. Materials and Methods. We assessed 73 children with SRNS admitted to Ali Asghar Children Hospital in Tehran, Iran. Their clinical presentations, treatment, and disease courses were reviewed. The mean follow-up duration was 6.0 ± 4.2 years. Moreover, survival times were calculated and the Cox regression method was used to determine variables able to predict survival of the kidneys. Results. Age at the onset of the disease, sex, and hematuria were not predictive of the response to treatment with immunosuppressive drugs in the children with SRNS. The type of resistance (early or late) was associated with the responsiveness to immunosuppressives. Response to any of the immunosuppressive drugs determined the responsiveness to other immunosuppressive drugs. Cyclosporine was more effective than cyclophosphamide as initial therapy. The mean kidney survival time was 11.62 years. Kidney survival rates were 94.6%, 70.0%, 56.0%, and 34.0% at 1, 5, 10, and 15 years, respectively, in patients with initial resistance to steroid, while these were 100%, 100%, 83.0%, and 83.0% in those with late resistance, respectively (P = .03). Conclusions. We showed that patients with late steroid resistance had better response to immunosuprressive drugs than patients with early resistance. We also showed that resistance to immunosuppressive therapies increased the risk of resistance to other immunosuppressive drugs. Achievement of complete or partial remission with any therapy reduced the risk of ESRD.
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نویسندگان مقاله حسن اتوکش | hassan otukesh


سلمان اتوکش | salman otukesh


مونا مجتهدزاده | mona mojtahedzadeh


رزیتا حسینی | rozita hoseini


سید محمد فرشته نژاد | seyed mohammad fereshtehnejad


اعظم ریاحی فرد | azam riahi fard


نادر صدیق | nader sadigh


اشکان حشمت زاده بهزادی | ashkan heshmatzade behzadi


ramila جوادی | ramila javadi


نکیسا هومن | nakissa hooman


میترا مهرآزما | mitra mehrazma


نشانی اینترنتی http://www.ijkd.org/index.php/ijkd/article/view/122
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده ORIGINAL | Kidney Diseases
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