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Iranian Journal of Kidney Diseases، جلد ۳، شماره ۲، صفحات ۸۰-۰
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عنوان انگلیسی Renoprotective Activity of Benincasa Cerifera Fruit Extract on Ischemia/Reperfusion-Induced Renal Damage in Rat
چکیده انگلیسی مقاله Introduction. Evidence suggests that reactive oxygen species play a role in the pathophysiology of renal ischemia/reperfusion (I/R) injury. This study was designed to investigate the renoprotective activity of methanolic fruit extract of Benincasa cerifera in I/R-induced kidney failure in rats. Materials and Methods. Renal pedicles of 12 rats were occluded for 60 minutes followed by 24 hours of reperfusion. Six days prior to induction of I/R, 6 of the rats received Benincasa cerifera, 500 mg/kg, orally. Serum creatinine, urea, and uric acid levels were measured after the operation. At the end of reperfusion period, the rats were sacrificed. Superoxide dismutage, catalase, reduced glutathione, and renal malondialdehyde content were determined in the renal tissues. Results were compared with a group of rats with sham operation. Results. Renal I/R caused significant impairment of kidney function. Six-day administration of Benincasa cerifera, however, minimized this effect. Rats with renal I/R only showed significantly decreased activity of superoxide dismutage, catalase, and reduced glutathione compared with the sham-operated rats. These declining trends were significantly less in the group treated with Benincasa cerifera compared with those in the I/R-only group (P = .008, P = .07, and P Conclusions. These findings imply that reactive oxygen species play a crucial role in I/R-induced kidney injury and Benincasa cerifera exerts renoprotective activity probably by the radical scavenging activity.
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نویسندگان مقاله yagnik bhalodia | yagnik bhalodia


nilesh kanzariya | nilesh kanzariya


rameshvar patel | rameshvar patel


natavarlal patel | natavarlal patel


jitendra vaghasiya | jitendra vaghasiya


nurudin jivani | nurudin jivani


hitesh raval | hitesh raval


نشانی اینترنتی http://www.ijkd.org/index.php/ijkd/article/view/111
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده ORIGINAL | Kidney Diseases
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