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Iranian Journal of Kidney Diseases، جلد ۳، شماره ۲، صفحات ۸۹-۰
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عنوان انگلیسی Diagnostic Potential of Urinary Tumor Necrosis Factor-Alpha in Children With Acute Pyelonephritis
چکیده انگلیسی مقاله Introduction. Tumor necrosis factor-alpha (TNF-?) is an important mediator of the inflammatory response in serious bacterial infections. The aim of this study was to evaluate the potential of urinary TNF-? for diagnosis of acute pyelonephritis in children. Materials and Methods. This study was conducted from March 2006 to December 2007 on children with confirmed diagnosis of acute pyelonephritis. They all had positive renal scintigraphy scans for pyelonephritis and leukocyturia. The ratios of urinary TNF-? to urine creatinine level were determined and compared in patients before and after antibiotic therapy. Results. Eighty-two children (13 boys and 69 girls) with acute pyelonephritis were evaluated. The mean pretreatment ratio of urinary TNF-? to urinary creatinine level was higher than that 3 days after starting on empirical treatment (P = .03). The sensitivity of this parameter was 91% for diagnosis of acute pyelonephritis when compared with demercaptosuccinic acid renal scintigraphy as gold standard. Conclusions. Based on our findings in children, the level of urinary TNF-?-creatinine ratio is acute increased in pyelonephritis and it decreases after appropriate therapy with a high sensitivity for early diagnosis of the disease. Further research is warranted for shedding light on the potential diagnostic role of urinary TNF-? in pyelonephritis in children.
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نویسندگان مقاله معصومه محکم | masoumeh mohkam


فهیمه عسگریان | fahimeh asgarian


علیرضا فهیم زاد | alireza fahimzad


مصطفی شریفیان | mostafa sharifian


رضا دلیرانی | reza dalirani


فاطمه عبدالله گرجی | fatemeh abdollah gorgi


نشانی اینترنتی http://www.ijkd.org/index.php/ijkd/article/view/113
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده ORIGINAL | Kidney Diseases
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