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Acta Medica Iranica، جلد ۵۵، شماره ۱۱، صفحات ۶۶۵-۶۷۱
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عنوان انگلیسی Association Between IL6-174 G/C Polymorphism and Graves' Disease: A Systematic Review and Meta-Analysis
چکیده انگلیسی مقاله Several studies have evaluated the association between interleukin-6 (IL-6) -174 G/C polymorphism and Graves' disease (GD); however, the results have been inconsistent. In the current study, a meta-analysis was performed to assess the association of IL6 -174 G/C polymorphism with Graves' disease . Medline, EMBASE , and Web of Science databases were searched to identify all eligible studies published before August 2016. Odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were calculated to assess the strength of association in dominant, recessive, allelic, homozygotes contrast, and heterozygotes contrast models. A total of four case-control studies with 554 GD cases and 1201 healthy controls were included in this meta-analysis. In the combined analysis, the results showed significant association between the IL6 -174 G/C polymorphism and the risk for GD in dominant model (OR=1.39, 95% CI: 1.07-1.80), recessive model (OR=2.75, 95% CI: 1.01-7.55) and homozygote contrast model (OR=3.25, 95% CI: 1.1-9.58). No publication bias was found in the current study (all P >0.05). The meta-analysis results suggested that the IL6 -174 G/C polymorphism was indicated to be associated with the risk of GD. Further studies are warranted to confirm these results.
کلیدواژه‌های انگلیسی مقاله Interleukin-6,Polymorphism,Graves,Meta-analysis
نویسندگان مقاله دانیال ایمانی | danyal imani
department of immunology, school of medicine, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

رمضان رضایی | ramazan rezaei
department of hematology, school of align medicine, tehran university of medical sciences tums , tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

بهمن رضی | bahman razi
department of cellular and molecular nutrition, school of nutritional sciences and dietetics, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

شهاب علیزاده | shahab alizadeh
rheumatology research center, tehran university of medical sciences, tehran, iran. and rheumatology expert group reg , universal scientific education and research network usern , tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مهدی محمودی | mahdi mahmoudi


نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/6205
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