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Acta Medica Iranica، جلد ۵۵، شماره ۱۱، صفحات ۶۷۲-۶۷۵
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عنوان انگلیسی Association of Transforming Growth Factor-Beta Gene Polymorphisms in Recurrent Aphthous Stomatitis
چکیده انگلیسی مقاله This study has been conducted to evaluate the allele, genotype and haplotype frequencies of the polymorphic gene coding TGF-β in recurrent aphthous stomatitis (RAS). TGF-β gene typing was done by polymerase chain reaction with sequence-specific primers (PCR-SSP) assay. Allele frequencies were estimated by direct gene counting. C allele at codon 25 was significantly increased, while G allele at this position was significantly decreased in patients compared to the controls. A significantly higher frequency of CG genotype at codon 25 was found in control group. CC genotype and TT genotype at codon 10 of the gene was significantly decreased, while CT genotype at the same position was significantly increased in patients, indicating that CT heterozygosity at codon 10 TGF-β is associated with greater risk of RAS. CG and TG haplotypes were significantly decreased while CC and TC haplotypes were significantly increased in patients compared with controls. This study indicates the TGF-β single nucleotide polymorphisms could play a role in RAS pathogenesis. Thereby certain SNPs of TGF-β gene have an association with RAS pathogenesis.
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نویسندگان مقاله هیلا یوسفی | hila yousefi
dental research center, school of dentistry, tehran university of medical sciences, tehran, iran. and department of oral medicine, school of dentistry, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

شمس الملوک نجفی | shamsolmoulouk najafi
department of orthodontic, dental branch, islamic azad university, tehran, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

مهسا محمدزاده | mahsa mohammadzadeh
department of immunology, school of medicine, tehran university of medical sciences, tehran, iran. and network of immunity in infection, malignancy and autoimmunity niima , universal scientific education and research network usern , canberra, australia.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

علیرضا زارع بیدکی | alireza zare bidoki
department of hematology, school of allied medical sciences, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

الهام فرهادی | elham farhadi
department of immunology, school of medicine, tehran university of medical sciences, tehran, iran. and 8 research center for immunodeficiencies, children’s medical center, tehran university of medical sciences, tehran, iran. and network of immunity in infection, malignancy and autoimmunity niima , universal scientific education and research network usern , tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نیما رضایی | nima rezaei


نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/5565
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