| چکیده انگلیسی مقاله |
Juvenile idiopathic arthritis (JIA) is a clinically heterogeneous cluster of complex diseases, in which both the genetic and environmental factors seem to play a role in the development of the disease. The current study aims to assess the association of programmed cell death 1 (PDCD1, also called PD-1) gene variants with JIA vulnerability in Iranian population. In this case-control association study, we investigated a group of 50 Iranian patients with JIA in comparison with 202 healthy controls and evaluated the frequency of alleles, genotypes, and haplotypes of PDCD1 single-nucleotide polymorphisms (SNPs), comprising PD-1.1 G/A, PD-1.3 G/A and PD-1.9 C/T, using PCR-RFLP method. Both the allelic and genotype frequencies of PD-1.1 , PD-1.3 and PD-1.9 were similar in two groups of patients and controls. Moreover, no significant difference was observed between the two groups of patients and controls for GGC ( PD-1.1 G, PD-1.3 G, PD-1.9 C), GAC ( PD-1.1 G, PD-1.3 A, PD-1.9 C), and AGT ( PD-1.1 A, PD-1.3 G, PD-1.9 T) haplotypes. Our results did not show any association between PDCD1 SNPs and the development of JIA in Iranian population. |
| نویسندگان مقاله |
مهدی محمودی | mahdi mahmoudi
rheumatology research center, tehran university of medical sciences, tehran, iran. and department of immunology, school of medicine, tehran university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
علیرضا رضایی منش | alireza rezaiemanesh
molecular immunology research center, school of medicine, tehran university of medical sciences, tehran, iran. and network of immunity in infection, malignancy and autoimmunity niima , universal scientific education and research network usern , tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
سارا هرسینی | sara harsini
research center for immunodeficiencies, children’s medical center, tehran university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
آرش سلمانی نژاد | arash salmaninejad
rheumatology research center, tehran university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
شیوا poursani | shiva poursani
department of medical genetics, school of medicine, tehran university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
طیب بهرامی | tayyeb bahrami
department of pediatrics, children’s medical center, tehran university of medical sciences, tehran, iran. and pediatric rheumatology research group, rheumatology research center, tehran university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
وحید ضیایی | vahid ziaee
department of immunology, school of medicine, tehran university of medical sciences, tehran, iran. and network of immunity in infection, malignancy and autoimmunity niima , universal scientific education and research network usern , tehran, iran. and research center for immunodeficiencies, children’s medical center, tehran university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
نیما رضایی | nima rezaei
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