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Iranian Journal of Kidney Diseases، جلد ۲، شماره ۴، صفحات ۱۹۳-۰
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عنوان انگلیسی Urinary Interleukin-8 in Acute Pyelonephritis of Children: A Before-After Study
چکیده انگلیسی مقاله Normal 0 false false false MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Introduction. The aim of this study was to assess urinary interleukin-8 (IL-8) levels in pyelonephritis and its relation with the clinical course of the infection and of inflammatory changes detected by renal scintigraphy. Materials and Methods. In this quasi-experimental before-after study, we evaluated 91 children aged 1 to 144 months (mean 34.4 ± 35.2 months) with pyelonephritis. Inflammatory markers including erythrocyte sedimentation rate, C-reactive protein, leukocyte count, and urinary IL-8, together with the results of ultrasonography, voiding cystourethrography, and dimercaptosuccinic acid renal scintigraphy were evaluated in these children. The ratios of urinary IL-8 to creatinine (IL-8/C) before and after the treatment were compared with each other. Results. Urinary IL-8/C levels were significantly higher after the empirical treatment in comparison with those before the treatment (0.19 ± 0.21 versus 0.51 ± 0.53, P leukocyturia, urine culture results, other inflammatory markers, or findings of imaging examinations. Conclusions. We found high urinary IL-8 levels in children with pyelonephritis. We also documented its increasing after the treatment. We conclude that evaluation of urinary IL-8 can be a noninvasive test for diagnosis of upper urinary tract infection and its response to treatment.
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نویسندگان مقاله معصومه محکم | masoumeh mohkam


عبدالله کریمی | abdollah karimi


حسین کریمی | hossein karimi


مصطفی شریفیان | mostafa sharifian


شهناز آرمین | shahnaz armin


رضا دلیرانی | reza dalirani


فاطمه عبدالله گرجی | fatemeh abdollah gorgi


نشانی اینترنتی http://www.ijkd.org/index.php/ijkd/article/view/18
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده ORIGINAL | Kidney Diseases
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