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Iranian Journal of Kidney Diseases، جلد ۲، شماره ۴، صفحات ۲۲۷-۰
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عنوان انگلیسی Posttransplant Lymphoproliferative Disorders in Kidney Transplant Recipients: An Iranian Multicenter Experience
چکیده انگلیسی مقاله Normal 0 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } Normal 0 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Introduction. Limited data with adequate sample size exist on the development of posttransplant lymphoproliferative disorder (PTLD) in living donor kidney recipients. W e conducted a retrospective cohort study on the data of 10 transplant centers to identify the incidence of PTLD in Iran. Materials and Methods. Data of 9917 kidney transplant recipients who received their kidneys between 1984 and 200 8 were reviewed. Fifty-one recipients (0.5%) who developed PTLD were evaluated with a median follow-up of 47.5 months (range, 1 to 211) months. Results. Patients with PTLD represented 24% of all posttransplant malignancies (51 out of 211 cases). There was no relationship between PTLD and sex ( P = .20). There were no statistically significance differences considering the age at transplantation between patients with and without PTLD . The late-onset PTLD (70.6%) occurred more frequently compared to the early form. There was no signification relationship between early-onset and late-onset groups in terms of clinical course and outcome. In patients who received azathioprine, PTLD was more frequent when compared to those who received mycophenolate mofetil ( P The lymph nodes were the predominantly involved site (35.3%), followed by the gastrointestinal tract, brain, kidney allograft, lung, ovary, vertebrae, and palatine. Age at diagnosis and the time from transplantation to diagnosis were comparable for various involvement sites of PTLDs. The overall mortality in this series of patients was 51.0%. Conclusions. P osttransplant lymphoproliferative disorder is a rare but devastating complication and long-term prognosis can be improved with early recognition and appropriate therapy.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله بهزاد عین اللهی | behzad einollahi


محبوب دکتر محبوب لسان پزشکی | mahboob lessan pezeshki


محمد حسین نوربالا | mohammad hossein nourbala


ناصر سیم فروش | nasser simforoosh


وحید وحید | vahid pourfarziani


اقلیم نعمتی | eghlim nemati


محسن نفر | mohsen nafar


عباس بصیری | abbas basiri


فاطمه پور رضا قلی | fatemeh pour reza gholi


احمد فیروزان | ahmad firoozan


محمد حسن قدیانی | mohammad hassan ghadiani


خدیجه مخدومی | khadijeh makhdoomi


علی غفاری | ali ghafari


پدرام احمدپور | pedram ahmadpour


فرشید اولیایی | farshid oliaei


محمدرضا اردلان | mohammad reza ardalan


عطیه مخلوق | atieh makhlough


حمیدرضا سامی مقام | hamid reza samimagham


جلال آزمندیان | jalal azmandian


عفت رازقی | efat razeghi


حشمت اله شهبازیان | heshmatollah shahbazian


نشانی اینترنتی http://www.ijkd.org/index.php/ijkd/article/view/25
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده ORIGINAL | Transplantation
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