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Iranian Journal of Kidney Diseases، جلد ۲، شماره ۲، صفحات ۷۲-۰
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عنوان انگلیسی Interleukin-6 and C-Reactive Protein in Pathogenesis of Diabetic Nephropathy: New Evidence Linking Inflammation, Glycemic Control, and Microalbuminuria
چکیده انگلیسی مقاله Introduction. Recent studies have shown that subclinical inflammation is a part of type 2 diabetes mellitus. This study was designed to explore the relationships between low-grade inflammation and renal microangiopathy in patients with type 2 diabetes mellitus. Materials and Methods. Sixty patients with type 2 diabetes mellitus were included in the study and further divided into normoalbuminurics, microalbuminurics, and macroalbuminurics, of 20 patients each. We analyzed serum concentrations of high-sensitivity C-reactive protein (HS-CRP) and interleukin-6 (IL-6) and studied their correlation with proteinuria. The patients and a control group of 20 healthy individuals were followed-up for a period of 6 months and the markers measured again. Results. A positive correlation was found between urinary albumin excretion and levels of HS-CRP (r = 0.781, P Conclusions. Inflammatory markers in early type 2 diabetic nephropathy are elevated and are independently associated with urinary albumin excretion. It is possible to hypothesize on the participation of locally released cytokines in the development of kidney damage.
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نویسندگان مقاله nikhil choudhary choudhary | nikhil choudhary choudhary


ravinder s ahlawat | ravinder s ahlawat


نشانی اینترنتی http://www.ijkd.org/index.php/ijkd/article/view/81
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده ORIGINAL | Kidney Diseases
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