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Iranian Journal of Kidney Diseases، جلد ۲، شماره ۱، صفحات ۱۶-۰
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عنوان انگلیسی Relation Between Thyroid Hormone Concentration and Serum Levels of Interleukin-6 and Interleukin-10 in Patients With Nonthyroidal Illness Including Chronic Kidney Disease
چکیده انگلیسی مقاله Introduction. We evaluated relations between interleukins (IL) IL-6 and IL-10 and euthyroid sick syndrome (ESS) in patients with nonthyroidal illness (NTI). Materials and Methods. Sixty patients and 20 healthy volunteers were recruited. The patients had either chronic kidney disease (CKD), congestive heart failure (CHF), or acute myocardial infarction (MI), distributed equally in 3 subgroups. Serum levels of IL-6 and IL-10, thyroid stimulating hormone (TSH), total T4, and T3 were determined. Results. In the 60 patients with NTI, we detected a significantly lower T3 and T4 levels compared to controls, while TSH level was within the reference range. Also, IL-6 level was substantially higher than that in controls (P Conclusions. The high frequency of ESS in patients with NTI may be linked to IL-6 and IL-10 alterations. Perturbation of IL-6, and not IL-10, might be involved in the pathogenesis of ESS along with other key players as suggested by our findings in CKD.
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نویسندگان مقاله hamdy abozenah | hamdy abozenah


صبری shoeb | sabry shoeb


سید علا صبری | alaa sabry


هشام اسماعیل | hesham ismail


نشانی اینترنتی http://www.ijkd.org/index.php/ijkd/article/view/64
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده ORIGINAL | Kidney Diseases
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