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Iranian Journal of Kidney Diseases، جلد ۲، شماره ۱، صفحات ۲۴-۰
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عنوان انگلیسی Urinary N-Acetyl-Beta-D-Glucosaminidase as a Diagnostic Marker of Acute Pyelonephritis in Children
چکیده انگلیسی مقاله Introduction. Prompt diagnosis and localization of pyelonephritis are of great importance in children. The urinary excretion of enzymes, and in particular N-acetyl-beta-D-glucosaminidase (NAG), is considered a simple noninvasive marker for detection of renal tubular dysfunction due to pyelonephritis. This study was performed to determine the diagnostic value of urinary NAG in acute pyelonephritis. Materials and Methods. In a quasi-experimental study conducted on 72 children with confirmed pyelonephritis, we measured urinary NAG, creatinine, and NAG-creatinine ratio before and after the treatment. Diagnostic values of these parameters were evaluated by considering the patients before and after the treatment as disease-positive and disease-negative groups, respectively. Results. The patients were 18 boys (25.0%) and 54 girls (75.0%) with a mean age of 43.0 ± 39.0 months. The mean levels of urinary NAG were 12.20 ± 6.14 U/L and 5.46 ± 7.98 U/L before and after the treatment, respectively (P Conclusions. We concluded that urinary NAG is elevated in children with pyelonephritis and it can be considered as a further criterion in the diagnosis of upper urinary tract infection.
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نویسندگان مقاله معصومه محکم | masoumeh mohkam


عبدالله کریمی | abdollah karimi


سعید حبیبیان | saiid habibian


مصطفی شریفیان | mostafa sharifian


نشانی اینترنتی http://www.ijkd.org/index.php/ijkd/article/view/71
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده ORIGINAL | Kidney Diseases
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