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Iranian Journal of Medical Sciences، جلد ۴۳، شماره ۱، صفحات ۲۶-۰
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عنوان انگلیسی Regression of Nonalcoholic Fatty Liver Disease with Zinc and Selenium Co-supplementation after Disease Progression in Rats
چکیده انگلیسی مقاله Background: Studies have shown that zinc and selenium deficiency is common in nonalcoholic fatty liver disease (NAFLD). However, the effects of zinc and selenium co-supplementation before and/or after disease progression on NAFLD are not clear enough. The aim of this study was to compare the effects of zinc and selenium co-supplementation before and/or after disease progression on NAFLD prognosis. Methods: Forty male Sprague–Dawley rats (197±4 g) were randomly assigned to 4 dietary groups: normal-fat diet (NFD; receiving 9% of calories as fat), high-fat diet (HFD; receiving 82% of calories as fat), supplementation before disease progression (S+HFD), and supplementation after disease progression (HFD+S). The diets were implemented over a 20-week period in all the groups. Biochemical and histologic parameters were compared between the 4 groups, and between-group comparisons were also carried out. Results: There were significant differences in the average food dietary intake (P< 0.001), weight (P< 0.001), fasting blood sugar (P=0.005), triglyceride (P< 0.001), total cholesterol (P< 0.001), low-density lipoprotein cholesterol (P=0.002), high-density lipoprotein cholesterol (P=0.001), alanine aminotransferase (P< 0.001), and aspartate aminotransferase (P< 0.001) between the 4 dietary groups. Serum triglyceride and total cholesterol were significantly lower in the HFD+S Group than in the S+HFD Group (P< 0.001 and P=0.003, respectively). Fat accumulation was significantly reduced in the HFD+S Group (P< 0.001). Conclusion: Zinc and selenium co-supplementation after disease progression improved biochemical and histologic parameters in an experimental model of NAFLD.
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نویسندگان مقاله فرزاد شیدفر | farzad shidfar
iran national science foundation, tehran, iran; and colorectal research center, iran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

امیرحسین فقیهی | amirhosein faghihi
iran national science foundation, tehran, iran; and department of nutrition, school of public health, iran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

حمید لروند امیری | hamid lorvand amiri
iran national science foundation, tehran, iran; and department of biochemistry and nutrition, school of medicine, zanjan university of medical sciences, zanjan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زنجان (Zanjan university of medical sciences)

سیده ندا موسوی | seyedeh neda mousavi


نشانی اینترنتی http://ijms.sums.ac.ir/index.php/IJMS/article/view/3216
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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