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Iranian Journal of Medical Sciences، جلد ۴۲، شماره ۶، صفحات ۵۶۱-۰
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عنوان انگلیسی Effects of Subacute Administration of Co-Trimoxazole and Folic Acid on Ovarian Tissue in Adult Female Rats
چکیده انگلیسی مقاله Background: Previous studies have reported the antifertility activities of sulfonamides. This study was designed to evaluate the effects of co-trimoxazole and its co-administration with folic acid on ovarian tissue in female rats. Methods: A total of 54 rats were randomly divided into 9 groups (n=6) . Group I served as the control and group II (vehicle) received saline. Other groups, III to IX, received co-trimoxazole (30, 60, and 120 mg/kg; i.p.), folic acid (1 mg/kg; i.p.) or their combination for 14 days, respectively. The oocytes were obtained from each group at the end of the 14 th days and scored for maturational status as germinal vesicle (GV), metaphase I (MI), or metaphase II (MII). The number of primordial follicle (PrF), primary follicle (PF), and secondary follicle in formalin-fixed ovaries were counted under light microscopy. The data were analyzed by one-way ANOVA followed by post-hoc Dunnet test using SPSS statistical software (version 17.0) . Results were considered statistically significant at P< 0.05. Results: Co-trimoxazole (60 and 120 mg/kg) treatment for 14 days caused a significant decrease in the number of GV (P=0.02, P< 0.001), MI and MII (P=0.03, P< 0.001), a significant increase in structural abnormalities, including PrF, PF and secondary follicle (P< 0.001) as well as congestion, inflammation and necrosis of ovarian tissue compared to the vehicle group. Folic acid co-administration with co-trimoxazole reversed partially all these parameters compared to the co-trimoxazole group (P< 0.001). Conclusion: The data showed the adverse effects of co-trimoxazole on the ovarian maturational status and tissue structure which was reversed partially by folic acid co-administration in rats. 
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نویسندگان مقاله آرزو صابری | arezoo saberi
kerman physiology research center, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

احسان سالارکیا | ehsan salarkia
endocrinology and metabolism research center, institute of basic and clinical physiology sciences, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

زهره صافی | zohreh safi
kerman neuroscience research center, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

غلامرضا سپهری | gholamreza sepehri


نشانی اینترنتی http://ijms.sums.ac.ir/index.php/IJMS/article/view/3156
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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