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Iranian Journal of Medical Sciences، جلد ۴۲، شماره ۶، صفحات ۵۶۹-۰
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عنوان انگلیسی Long-term Low-Intensity Endurance Exercise along with Blood-Flow Restriction Improves Muscle Mass and Neuromuscular Junction Compartments in Old Rats
چکیده انگلیسی مقاله Background: During the aging process, muscle atrophy and neuromuscular junction remodeling are inevitable. The present study aimed to clarify whether low-intensity aerobic exercise along with limb blood-flow restriction (BFR) could improve aging-induced muscle atrophy and nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. Methods: Forty-eight male Wistar rats, aged 23–24 months, were randomly divided into control, sham (Sh: subjected to surgery without BFR), BFR (subjected to BFR), exercise (Ex: subjected to 10 weeks of low-intensity exercise), Sh+Ex, and BFR+Ex groups. Forty-eight hours after the last training session, the animals were sacrificed and their soleus and extensor digitorum longus (EDL) muscles were removed. The hypertrophy index was calculated, and molecular parameters were measured using western blotting. Statistical analysis was done with ANOVA using SPSS (version 20), with a P< 0.05 as the level of significance. Results: The control and Sh groups showed weight gain (P=0.001), whereas the Ex, Sh+Ex, and BFR+Ex groups had significant weight loss (P< 0.001). The hypertrophy index of the soleus was significantly higher in the BFR+Ex group than in the control, Sh, and BFR groups (P< 0.001). BFR+Ex induced significant hypertrophic effects on the EDL (P< 0.001 vs. the control, Sh, Ex, and Sh+Ex groups, and P=0.006 vs. the BFR group). BFR+Ex also increased nAChRs in the soleus (P=0.02 vs. the control and Sh groups) and the EDL (P=0.008 vs. the control and Sh groups). Conclusion: BFR plus mild exercise is a safe method with potential beneficial effects in protecting and augmenting muscle mass and nAChR clustering at the neuromuscular junction in old rats.
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نویسندگان مقاله محمد علی بحرینی پور | mohammad ali bahreini pour
neuroscience research center, institute of neuropharmacology, kerman university of medical sciences, kerman, iran; and physiology research center, institute of basic and clinical physiology sciences, kerman university of medical sciences, kerman, iran; and cardiovascular research center, institute of basic and clinical physiology sciences, kerman university of medical science, kerman, iran; and department of physiology and pharmacology, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

سیاوش جوکار | siyavash joukar
phisical education and sports science college, shahid beheshti university, tehran, iran

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

فریبرز هوانلو | fariborz hovanloo
cardiovascular research center, institute of basic and clinical physiology sciences, kerman university of medical science, kerman, iran; and department of physiology and pharmacology, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

حمید نجفی پور | hamid najafipour


نشانی اینترنتی http://ijms.sums.ac.ir/index.php/IJMS/article/view/3989
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زبان مقاله منتشر شده en
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