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Iranian Journal of Basic Medical Sciences، جلد ۲۱، شماره ۳، صفحات ۲۳۰-۲۳۵
عنوان فارسی
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عنوان انگلیسی Amelioration of carbon tetrachloride-induced hepatic injury by emulsified Antrodia extract
چکیده انگلیسی مقاله Objective(s): Antrodia cinnamomea (AC) is found with anti-inflammatory and immunomodulatory biological activities. In this study, we investigated the anti-hepatitis effect of the emulsified AC extract from RO water or supercritical fluid CO2 with ethanol co-solvent extract methods of AC preparations. Materials and Methods: Five groups of eight to ten weeks male rats with a count of ten for each group were studied to evaluate the protection of two kinds of AC extract from hepatic injury. Acute liver injury of rats was induced by injecting 40% carbon tetrachloride (CCl4) 1 mg/kg intraperitoneally. Positive and negative control groups rats were perfused with CCl4 or isotonic saline, respectively. Experimental groups received oral administration once/day of AC preparations before CCl4 treatment: water AC extract (WAE group), or emulsified AC extract from supercritical fluid extraction (EAE group) for 5 days, and sacrificed on the 6th day and the blood and liver samples were collected under chloral hydrate anesthesia. The anti-inflammatory, antioxidant markers, and relevant signaling pathways were measured (AST, ALT, ROS, IL-1, IL-6, NO, and COX-2, MAPKs, and caspase-3). Results: EAE at 50 mg/kg significantly decreased the serum AST, ALT, IL-1, IL-6, NO, and ROS levels. Both extracts reduced the activation of p-ERK in the liver samples, but EAE inhibited COX-2 and caspase-3 protein expression better than WAE. The EAE ameliorated CCl4-induced hepatic injury significantly; as compared with WAE and the positive control. Conclusion: The hepatoprotection of EAE could be attributed to the antioxidant and anti-inflammatory effects of Antrodia.
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نویسندگان مقاله wei chih چنگ | wei chih chang
graduate institute of bioresources, national pingtung university of science and technology, pingtung, taiwan


چنگ tsen هانگ | chang tsen hung
department of health and leisure management, yuanpei university of medical technology, hsinchu, taiwan


yuh shuen chen | yuh shuen chen
department of food science and technology, hungkuang university, taichung, taiwan


chih chi hsueh | chih chi hsueh
department of biotechnology and pharmaceutical technology, yuanpei university of medical technology, hsinchu, taiwan


chien wei hou | chien wei hou
department of biotechnology and pharmaceutical technology, yuanpei university of medical technology, hsinchu, taiwan


horng لیان لای | horng lian lay
department of plant industry, national pingtung university of science and technology, pingtung, taiwan
نشانی اینترنتی http://ijbms.mums.ac.ir/article_10194.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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