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Iranian Journal of Basic Medical Sciences، جلد ۲۱، شماره ۳، صفحات ۳۴۲-۳۴۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Anti-diabetic effects of Sargassum oligocystum on Streptozotocin- induced diabetic rat
چکیده انگلیسی مقاله Objective(s): Diabetes is a metabolic syndrome which is associated with the worldwide major public health problems. There are many natural compounds from the sea-market, as a valuable aquatic source, along with the variety of health and therapeutic benefits. In the present research, with respect to the traditional and ethnic uses of Sargassum oligocystum algae for healing of some diseases which have similar metabolic mechanism to the diabetes, its anti-diabetic effects in animal model was proposed. Materials and Methods: The animals (rat) were divided into the normal control, diabetic control, positive control and, the test groups. The test groups were gavaged with oral doses of 150 and 300 mg/kg of algae hydroalcoholic extracts. After 30 days of intervention the serum glucose, cholesterol, triglyceride, HDLC, LDLC, insulin, insulin resistance, β-cells function and, the histopathology of pancreatic tissue were evaluated. Results: In animals that were fed with algae extracts a significant decrease in the fasting blood glucose, triglyceride and HOMA-IR and an increase in the HOMA-B with no significant impacts on the insulin, cholesterol and HDL were observed. Also, the histopathology evaluations in the groups which were treated with algae extract revealed the regeneration and reconstitution of damaged pancreatic β-cells. Conclusion: The results give evidence that, the S. oligocystum algae extract has a healing effect on diabetes which can be considered as a new research prospect for the natural therapy of diabetes.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله صمد اکبرزاده | samad akbarzadeh
departments of biochemistry, school of medicine, bushehr university of medical sciences, bushehr, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بوشهر (Bushehr university of medical sciences)

حسین غلامپور | hossein gholampour
the student’s committee research, school of medicine, bushehr university of medical sciences, bushehr, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بوشهر (Bushehr university of medical sciences)

پرویز فرزادی نیا | parviz farzadinia
departments of anatomy, school of medicine, bushehr university of medical sciences, bushehr, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بوشهر (Bushehr university of medical sciences)

عادل دانشی | adel daneshi
the persian gulf marine biotechnology research center, bushehr university of medical sciences, bushehr, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بوشهر (Bushehr university of medical sciences)

بهمن رماوندی | bahman ramavandi
departments of environmental health engineering, faculty of health, bushehr university of medical sciences, bushehr, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بوشهر (Bushehr university of medical sciences)

علی موذنی | ali moazzeni
departments of hematology, faculty of allied medicine, bushehr university of medical sciences, bushehr, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بوشهر (Bushehr university of medical sciences)

مجتبی کشاورز | mojtaba keshavarz
departments of pharmacology, school of medicine, bushehr university of medical sciences, bushehr, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بوشهر (Bushehr university of medical sciences)

افشار بارگاهی | afshar bargahi
departments of biochemistry, school of medicine, bushehr university of medical sciences, bushehr, iran|the persian gulf marine biotechnology research center, bushehr university of medical sciences, bushehr, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بوشهر (Bushehr university of medical sciences)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_10195.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-565996.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Short Communication
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