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Research Journal of Pharmacognosy، جلد ۴، شماره Supplement، صفحات ۷۹-۷۹
عنوان فارسی
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عنوان انگلیسی Marrubium parviflorum Fisch. & C.A.Mey.; phytochemical constituents and antioxidant activity
چکیده انگلیسی مقاله Background and objectives: Marrubium parviflorum Fisch. & C.A.Mey. (Lamiaceae) is a medicinal plant with documented antioxidant and analgesic effects distributed in Iran and Turkey. In the present study, the aerial parts of this species were subjected to phytochemical analysis, as well as antioxidant activity assays. Methods: Antioxidant activity of the petroleum ether, chloroform, ethyl acetate and n-butanol fractions of M. parviflorum aerial parts were evaluated using DPPH free radical-scavenging assay. Phytochemical constituents of the fractions having the most antioxidant activity were investigated on silica gel (normal and reversed phases) and sephadex LH-20 columns. Structures of the isolated compounds were elucidated using 1H-NMR, 13C-NMR and UV spectral analyses. Result: In DPPH free radical-scavenging assay, the ethyl acetate and n-butanol fractions demonstrated considerable antioxidant activity with IC50 values of 84.1 ± 5.1 and 85.6 ± 3.4 µg/mL, respectively. Phytochemical investigation of the mentioned fractions resulted in the isolation of eleven compounds including forsythoside B (1), verbascoside (2), quercetin-3-O-rutinoside (3), chlorogenic acid (4), quercetin-3-O-β-D-glucopyranoside (5), 1,5-dicaffeoylquinic acid (cynarin) (6), 4,5-dicaffeoylquinic acid (7), caffeic acid glucoside (8), chrysoeriol 7-O-(3''-O-E-p-coumaroyl)-β-D-glucopyranoside (9), chrysoeriol 7-O-(3'',6''-di-O-E-p-coumaroyl)-β-D-glucopyranoside (10) and apigenin 7-O-(6''-O-E-p-coumaroyl)-β-D-glucopyranoside (11). Conclusion: The results of this study introduced M. parviflorum as a plant rich in flavonoids, phenylethanoid glycosides and caffeoylquinic acid derivatives. A review on biological activity of the isolated compounds suggested the possible involvement of these compounds in previously reported antioxidant and analgesic activity of M. parviflorum. These findings were also indicated more medicinal potential of M. parviflorum and highlighted the species for further biological studies.    
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نویسندگان مقاله محمدرضا delnavazi | m r
department of pharmacognosy, faculty of pharmacy, tehran university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

n یاسا |
department of pharmacognosy, faculty of pharmacy, tehran university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

a شاکری |
school of chemistry, university of tehran, tehran, iran.
سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

p rostamiasrabadi |
department of pharmacognosy, faculty of pharmacy, tehran university of medical sciences, tehran, iran. school of chemistry, university of tehran, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://www.rjpharmacognosy.ir/article_53289_08c468e18170d60325192c35011dcca2.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/338/article-338-567120.pdf
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