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Acta Medica Iranica، جلد ۵۶، شماره ۱، صفحات ۱۴-۲۰
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عنوان انگلیسی Cromakalim, a Potassium Channel Opener, Ameliorates the Organophosphate and Carbamate-Induced Seizure in Mice
چکیده انگلیسی مقاله Organophosphates (OPs) and carbamates are acetylcholine esterase inhibitors (AChEIs), which can cause seizure and lethality. Anticonvulsant properties of potassium channel openers including cromakalim have been determined in previous studies. In the present experiment, the possible effect of cromakalim on the convulsion and death induced by OPs and carbamates was studied in mice. Dichlorvos (an OP, 50 mg/kg) and physostigmine (a carbamate, 2 mg/kg) were used to induce seizure in animals. Cromakalim at doses of 0.1, 10, and 30 µg/kg was injected 30 min before dichlorvos and physostigmine, and 5 min before glibenclamide (a potassium channel blocker, 1 mg/kg) administration. All injections were performed intraperitoneally. After drugs administration, the onset of convulsion, death, the severity of seizure, and rate of mortality were investigated. Results revealed that both dichlorvos and physostigmine induced seizure activity and lethality in 100% of the animals. Cromakalim at doses of 0.1, 10, and 30 µg/kg significantly increased the latency of both seizure and death ( P < 0.05). Also, cromakalim decreased the mortality rate induced by dichlorvos and physostigmine ( P < 0.05). On the other hand, glibenclamide blocked all aspects of the anticonvulsant effect of cromakalim ( P < 0.05). This study revealed for the first time that cromakalim (a K ATP channel opener) diminishes the seizure and death induced by dichlorvos and physostigmine in mice, and introduces a new aspect to manage the patients who suffer from OPs/carbamates-induced seizure.
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نویسندگان مقاله ستار ستار | sattar ostadhadi
department of periodontics, school of dentistry, alborz university of medical sciences, alborz, iran.


ابوذر مرادی | abouzar moradi
department of pharmacology, school of medicine, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سمیرا ذوالفقاری | samira zolfaghari
razi drug research center, iran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

وحید نیکویی | vahid nikoui
experimental medicine research center, tehran university of medical sciences, tehran, iran. and department of pharmacology, school of medicine, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

احمدرضا دهپور | ahmad reza dehpour


نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/6272
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/56/article-56-567293.pdf
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زبان مقاله منتشر شده en
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