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Iranian Journal of Pathology، جلد ۱۳، شماره ۱، صفحات ۶۳-۷۰
عنوان فارسی
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عنوان انگلیسی The Association between Ocular Problems and Serum Testosterone, Prolactin and Thyroglobulin Concentrations in Delayed Phase of Sulfur Mustard Exposure
چکیده انگلیسی مقاله Background and objective Aside from direct toxic effects, Sulfur Mustard (SM) induced serum hormone abnormalities may aggravate ocular complaints, including Ocular Surface Discomfort (OSD) (burning, itching, and redness), dry eye sensation, photophobia, blurred vision, foreign body sensation, and pain. The aim of the current study was to investigate the possible association of ocular complaints with serum hormone concentrations in chronic phase of Sulfur Mustard (SM) exposure. Methods:As a part of Sardasht Iran Cohort Study (SICS), 372 SM-exposed patients and 128 non-exposed participants were enrolled. Ocular complaints and ocular surface biomicroscopic conditions and serum hormones were compared. Results:The exposed with tearing group had significantly higher mean serum levels of testosterone and prolactin (ng/mL) than controls (5.75 vs. 4.75, P=0.031; 11.71 vs. 8.42, P=0.009). The exposed with OSD group had significantly higher mean serum levels of prolactin than controls (12.48 vs. 6.90, P=0.002). The exposed with photophobia group had significantly higher mean serum levels of testosterone than the matched exposed (6.25 vs. 5.65, P=0.013). The exposed with blurred vision group had significantly higher mean serum levels of Thyroglobulin (Tg) (ng/mL) than the matched exposed (65.73 vs. 32.6, P=0.003). Conclusion: Higher mean serum levels of testosterone (in exposed with tearing and photophobia) and prolactin (in exposed with tearing and OSD) may play protective roles against SM effects. Higher mean serum levels of Tg may deteriorate the tear film integrity and optical surface, which causes blurred vision. In the chronic phase of SM toxicity, some ocular surface problems are associated with alterations in the serum concentrations of testosterone, prolactin, and Tg.
کلیدواژه‌های انگلیسی مقاله Sulfur mustard, Eye Injuries, Serum, Hormones
نویسندگان مقاله حسن قاسمی |
immunoregulation research center, shahed university, tehran, i.r. iran
سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)

نیره عسکری |
dept. of biology, faculty of basic sciences, shahid bahonar university of kerman, kerman, i.r iran
سازمان اصلی تایید شده: دانشگاه شهید باهنر (Shahid bahonar university)

سکینه موید |
immunoregulation research center, shahed university, tehran, i.r. iran
سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)

سقراط فقیه زاده |
dept. of biostatistics and social medicine, zanjan university of medical sciences, zanjan, i.r. iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی زنجان (Zanjan university of medical sciences)

سوسن کبودانیان اردستانی | kabudanian ardestani
institute of biochemistry and biophysics, tehran university, tehran, i.r. iran
سازمان اصلی تایید شده: مرکز تحقیقات بیوشیمی و بیوفیزیک (Institute of biochemistry and biophysics)

الهام فقیه زاده |
immunoregulation research center, shahed university, tehran, i.r. iran
سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)

طوبی غضنفری |
immunoregulation research center, shahed university, tehran, i.r. iran
سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)

نشانی اینترنتی http://ijp.iranpath.org/article_29943_a68fea38fe4bdd65ba3517805b76e3cf.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/194/article-194-567790.pdf
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