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Iranian Journal of Pathology، جلد ۱۳، شماره ۱، صفحات ۷۱-۷۷
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عنوان انگلیسی Prognostic Significance of Reduction in Ki67 Index After Neoadjuvant Chemotherapy in Patients With Breast Cancer in Kerman Between 2009 And 2014
چکیده انگلیسی مقاله Background and objective:Breast cancer is the most common malignancy among women. The Neoadjuvant chemotherapy is the treatment of choice for non-operable tumors. The Ki67 is a proliferation marker that can be used to predict the therapeutic response to chemotherapy and the patients' prognosis. Methods: This retrospective study was carried out on 55 consecutive patients with breast cancer referred to a Training Tertiary Healthcare Center in Kerman, Iran since 2009 to 2014. After diagnostic approval, the tissue samples of patients were examined for estrogen and progesterone receptors, ki67 and HER2-neu markers by using immunohistochemical staining. Then the patients were treated with 6 cycles of Neoadjuvant chemotherapy regimens by Doxorubicin and Taxans or 4 chemotherapy cycles, containing Anthracycline and Cyclophosphamide and 4 cycles of Paclitaxel. After mastectomy, their samples were reexamined for ki67 again and classified into three groups (low: ki67< 15%), medium (Ki67 = 16-30%) and high (Ki67> 30%). Results: Before chemotherapy, 54.5% of the patients had high expression of Ki67. But after chemotherapy, 52.7 of the patients had complete therapeutic response showing that the Ki67 level was reduced significantly (P=0.003). Conclusion: Before and after Neoadjuvant chemotherapy, Ki67 measurements may be used as a predictive marker of therapeutic response.
کلیدواژه‌های انگلیسی مقاله Neoadjuvant Therapy, Ki 67, Breast cancer, Prognosis
نویسندگان مقاله وحید معاضد |
hematology and oncology division, dept of internal medicine, afzalipour kerman medical science university, kerman, iran

الهام جعفری |
pathology and stem cells research center, dept of pathology, afzalipour kerman medical science university, kerman, iran

بهجت کلانتری خاندانی | kalantari khandani
hematology and oncology division, dept of internal medicine, afzalipour kerman medical science university, kerman, iran

علی نعمتی |
hematology and oncology division, dept of internal medicine, afzalipour kerman medical science university, kerman, iran

سیدامیر بن رضوی |
dept. of internal medicine, afzalipour kerman medical science university, kerman, iran

نشانی اینترنتی http://ijp.iranpath.org/article_29944_5c2fba9243efb69816ca74a185acec5b.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/194/article-194-567791.pdf
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