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International Journal of Radiation Research، جلد ۱۵، شماره ۲، صفحات ۲۱۳-۲۱۸
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عنوان انگلیسی Human amniotic membrane effect on colorectal anastomosis in dogs undergoing radiotherapy with/without diverting stoma: An experimental preliminary study
چکیده انگلیسی مقاله Background: : Radiotherapy is an important factor which results in increase of anastomosis leakage. Diverting loop ileostomy has been usually performed after colorectal anastomosis with history of neo-adjuvant radiotherapy to decrease the chance of leakage. Considering this effect, we assessed the feasibility and outcome of human amniotic membrane in rectal anastomosis in dogs previously treated by high-dose radiotherapy. Materials and Methods: Twelve cross-breed male dogs with the age of 6-8 months and weighting 10-15 kg were randomly divided into four groups. Groups 1 and 2 received radiotherapy and 4 weeks later, single layer end to end anastomosis was performed for all the dogs; also, diverting loop ileostomy was placed in groups 1 and 3. Four weeks later, the anastomosis site was resected and sent for pathologic wound healing scoring. Data were analyzed by SPSS 16 software using Mann- Whitney test. Results: Two dogs (of group 1 and 2) died of peritonitis due to anastomosis leakage during the 2nd post operation week. There was no statistically significant difference in wound healing between the case and control groups (P-Value: 0.01). Conclusion: HAM had a protective role in colorectal anastomosis after neo-adjuvant radiation in cases without loop diverting ileostomy. It can be concluded that HAM placement is a feasible technique instead of diverting loop ileostomy in cases with neo-adjuvant radiotherapy and also in the benign colorectal diseases with high risk anastomoses.
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نویسندگان مقاله سید وحید حسینی | s v hosseini
shiraz university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

m دهقانی | m. dehghani
colorectal research center, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

h خضرایی | h. khazraei
colorectal research center, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

محمدیوسف کرمی | m y karami
student research committee, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

s کرباسی | s. karbasi
department of radiotherapy and oncology, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

سید حسین banihashmi | s h banihashmi
department of surgery, faculty of medicine, hormozgan university of medical sciences, bandar abbas, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی هرمزگان (Hormozgan university of medical sciences)

نشانی اینترنتی http://ijrr.com/browse.php?a_code=A-10-1-668&slc_lang=en&sid=en
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/42/article-42-568230.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده مرور و بررسی کلی
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