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Iranian Biomedical Journal، جلد ۲۱، شماره ۶، صفحات ۳۶۹-۳۷۹
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عنوان انگلیسی Physically Targeted Intravenous Polyurethane Nanoparticles for Controlled Release of Atorvastatin Calcium
چکیده انگلیسی مقاله Background: Intravenous drug delivery is an advantageous choice for rapid administration, immediate drug effect, and avoidance of first-pass metabolism in oral drug delivery. In this study, the synthesis, formulation, and characterization of atorvastatin-loaded polyurethane (PU) nanoparticles were investigated for intravenous route of administration. Method: First, PU was synthesized and characterized. Second, nanoparticles were prepared in four different ratios of drug to polymer through two different techniques, including emulsion-diffusion and single-emulsion. Finally, particle size and polydispersity index, shape and surface morphology, drug entrapment efficiency (EE), drug loading, and in vitro release were evaluated by dynamics light scattering, scanning electron microscopy, and UV visible spectroscopy, respectively. Results: Within two methods, the prepared nanoparticles had a spherical shape and a smooth surface with a diversity of size ranged from 174.04 nm to 277.24 nm in emulsion-diffusion and from 306.5 nm to 393.12 in the single-emulsion method. The highest EE was 84.76%, for (1:4) sample in the emulsion-diffusion method. It has also been shown that in vitro release of nanoparticles, using the emulsion-diffusion method, was sustained up to eight days by two mechanisms: drug diffusion and polymer relaxation. Conclusion: PU nanoparticles, that were prepared by the emulsion-diffusion method, could be used as effective carriers for the controlled drug delivery of poorly water soluble drugs such as atorvastatin calcium.
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نویسندگان مقاله بهناز سادات افتخاری | behnaz sadat eftekhari
biomedical engineering department, amirkabir university of technology, tehran, iran

سازمان اصلی تایید شده: دانشگاه صنعتی امیرکبیر (Amirkabir university of technology)

اکبر کارخانه | akbar karkhaneh
biomedical engineering department, amirkabir university of technology, tehran, iran

سازمان اصلی تایید شده: دانشگاه صنعتی امیرکبیر (Amirkabir university of technology)

علی علیزاده | ali alizadeh
nanotechnology research center, sharif university of technology, tehran, iran

سازمان اصلی تایید شده: دانشگاه صنعتی شریف (Sharif university of technology)

نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-662&slc_lang=en&sid=en
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/125/article-125-568565.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Related Fields
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