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Medical Laboratory Journal، جلد ۱۱، شماره ۶، صفحات ۲۳-۲۹
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عنوان انگلیسی Effects of 8 Weeks of Resistance Training and IGF-1 Injection on Biochemical Markers of Cancer and Colorectal Structures in Rats
چکیده انگلیسی مقاله ABSTRACT          Background and Objectives: We studied effects of eight weeks of resistance training and IGF-1 injection on serum level of IGF-1, IGFBP-3 and IGF-1/IGFBP-3 ratio in Wistar rats.           Methods: We randomly divided 28 male Wistar rats into four groups of saline-injected control (C), resistance training+saline injection (RS), resistance training+IGF-1 injection (RI) and IGF-1 injection (II). Resistance training protocol consisted of climbing a ladder (three days/week with 5 reps/3 sets) while carrying a weight suspended from the tail for eight weeks. IGF-1 and saline (1.5 µg/kg/day) were injected before and after exercise sessions. Serum IGF-1, IGFBP-3 and IGF-1/IGFBP-3 ratio and morphology of colorectal tissue were evaluated.           Results: Serum IGF-1 level and IGF-1/IGFBP-3 ratio decreased in the RS group compared to the other groups (P< 0.05). Rats in the RS group had higher IGFBP-3 level than those in the II and RI groups (P< 0.05). IGF-1 injection had no effect on morphology of colorectal tissue.           Conclusion: The resistance training reduces IGF-1 and increases IGFBP-3 levels, which might represent a link between resistance training and lower risk of colorectal cancer.          Keywords: Exercise, Colorectal Neoplasms, Insulin-Like Growth Factor-1, Insulin-Like Growth Factor Binding Protein-3.
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نویسندگان مقاله babisan عسکری | babisan askari
department of sport physiology, faculty of physical education and sport sciences, ferdowsi university of mashhad, mashhad, iran

سازمان اصلی تایید شده: دانشگاه فردوسی (Ferdowsi university)

ناهید بیژه | nahid bijeh
department of sport physiology, faculty of physical education and sport sciences, ferdowsi university of mashhad, mashhad, iran

سازمان اصلی تایید شده: دانشگاه فردوسی (Ferdowsi university)

امیر رشیدلمیر | amir rashid lamir
department of sport physiology, faculty of physical education and sport sciences, ferdowsi university of mashhad, mashhad, iran

سازمان اصلی تایید شده: دانشگاه فردوسی (Ferdowsi university)

نشانی اینترنتی http://goums.ac.ir/mljgoums/browse.php?a_code=A-10-1-487&slc_lang=fa&sid=en
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/168/article-168-568724.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده تحقیقی
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