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Medical Laboratory Journal، جلد ۱۱، شماره ۵، صفحات ۳۶-۴۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Anti-Leishmanial Activity of Pelargonium roseum Essential Oil on Growth of Leishmania infantum Promastigotes
چکیده انگلیسی مقاله ABSTRACT          Background and Objectives: Due to adverse effects of pentavalent  antimonial  treatment of visceral leishmaniasis using herbal medicines has received a lot of attention. In this study, we evaluated inhibitory activity of Pelargonium roseum essential oil on growth of Leishmania infantum promastigotes, and compared it with that of Glucantime.         Methods: Inhibitory effects of different concentrations (1, 2.5, 5, 10, 25, 50 and 100 µL/ml) of P. roseum essential oil on the growth of L. infantum promastigotes were studied by MTT assay after 24 and 48 hours. All the data were analyzed by one-way analysis of variance. The effect of the essential oil was later compared with that of standard dose of Glucantime.         Results: After 24 hours, different concentrations of the essential oil had no significant inhibitory effect on promastigotes of L. infantum. After 48 hours, all concentrations except for 1µL/ml showed significant anti-leishmanial activity. In addition, the lowest concentration that had significant inhibitory effect on L. infantum promastigote was 5 µL/ml.        Conclusion: The essential oil of P. roseum has favorable inhibitory activity on the growth of L. infantum promastigotes after 48 hours. This indicates the therapeutic potential of this plant for treatment of leishmaniasis.         Keywords: Leishmania infantum, Pelargonium, Promastigote, Meglumine antimoniate.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله محدثه ابوحسینی طبری | mohaddeseh abouhosseini tabari
faculty of veterinary medicine, amol university of special moderntechnologies, amol, iran


محمدرضا یوسفی | mohammad reza youssefi
department of veterinary parasitology, babol-branch, islamic azad university, babol, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

بی بی راضیه حسینی فراش | bibi razieh hosseini farash
department of parasitology and mycology, faculty of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

محمد امین ابراهیمی | mohammad amin ebrahimi
young researcher and elite club, babol -branch,islamic azad university, babol-branch, babol, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

نیکی نبوی موسوی | niki nabavi mousavi
young researcher and elite club, babol- branch, islamic azad university, babol-branch, babol, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

الهام مقدس | elham moghaddas
department of parasitology and mycology, faculty of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://goums.ac.ir/mljgoums/browse.php?a_code=A-10-1-476&slc_lang=fa&sid=en
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/168/article-168-568727.pdf
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زبان مقاله منتشر شده en
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