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Research in Pharmaceutical Sciences، جلد ۱۱، شماره ۱، صفحات ۱۵-۰
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عنوان انگلیسی Antinociceptive effect of aqueous extracts from the bark of Croton guatemalensis Lotsy in mice
چکیده انگلیسی مقاله Croton guatemalensis Lotsy (CGL), known as “copalchi” in Chiapas, Mexico, is used for the treatment of fever, abdominal pain and malaria and also as a remedy for chills and for treating rheumatism. The aim of this study was to evaluate whether aqueous extracts from the bark of this plant possesses indeed antinociceptive properties by using two different animal models of nociception, the acetic acid-induced writhing test and the hot plate model. The results showed that i.p. administration of this extract (0, 100, 200 and 400 mg/kg) 30 min prior testing had significant dose-dependent antinociceptive effects in the acetic acid-induced writhing test and that the reduction of writhings (85.5 % as compared to the control) at the highest dose tested is similar to that exhibited by dipyrone (250 mg/kg). This effect was not reversed by naloxone, a non-selective opioid receptor antagonist, suggesting that the endogenous opioid system does not underlie the antinociceptive effects of CGL in the acetic acid-induced writhing test. No effects were however observed in the hot-plate model. Our results indicate that aqueous extracts from Croton guatemalensis bark contain pharmacologically active constituents endowed with antinociceptive activity. It is suggested that cyclooxygenase inhibition might be at least partially involved in the antinociceptive effects of this extract.
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نویسندگان مقاله rejón orantes جوز خندان carmen | rejón orantes josé del carmen


hernández macías جان willam | hernández macías john willam


grajales morales azucena خندان carmen | grajales morales azucena del carmen


jiménez گارسیا nataly | jiménez garcía nataly


coutiño ochoa samantha stefany | coutiño ochoa samantha stefany


cañas avalos anahi | cañas avalos anahi


parcero تورس jorge domingo | parcero torres jorge domingo


gordillo páez لیوناردو | gordillo páez leonardo


pérez de la مراد میگویل | pérez de la mora miguel


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1667
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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