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World Journal of Plastic Surgery، جلد ۷، شماره ۱، صفحات ۰-۰
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عنوان انگلیسی The Wound Healing Effects of Herbal Cream Containing Oliveria Decumbens and Pelargonium Graveolens Essential Oils in Diabetic Foot Ulcer Model
چکیده انگلیسی مقاله BACKGROUND The number of diabetic patients in adult population is increasing. All this population are at risk of developing diabetic foot ulcers (DFUs) that are associated with unwanted ailments and high mortality. In spite of current therapies for DFUs, further therapies are needed to help the patients. METHODS The efficacy of herbal cream containing Pelargonium graveolens and Oliveria decombens essential oils was evaluated topically for treatment of DFUs in rat animal model in comparison with two other herbal formulas containing each essential oil alone, placebo (the basic formula without active ingredients) and normal saline as control groups. After anesthesia of diabetic rats (n=75) induced by streptozotocin (STZ), diabetic wounds were visible on the hind dorsal surface of the foot. The treatments were initiated on Day 1 and repeated 3 times in a day for thirteen consecutive days. On day 1, 3, 5, 8 and 13, the wound sizes were determined and assessed histologically. RESULTS Three herbal formulations reduced the size of wounds in rats with DFUs, while the cream containing combined herbals of O. decumbens and P. graveolens essential oils had the highest tissue repair in DFU rat models. CONCLUSION Due to better wound healing effects of combined herbal cream containing O. decumbens and P. graveolens essential oils, it can be recommended in treatment of DFUs.
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نویسندگان مقاله محدثه محبوبی | mohaddese mahboubi
microbiology department, medicinal plant research center of barij, kashan, iran


محسن تقی زاده | mohsen taghizadeh
research center for biochemistry and nutrition in metabolic diseases, kashan university of medical sciences, kashan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کاشان (Kashan university of medical sciences)

طاهره خامه چیان | tahereh khamechian
department of pathology, faculty of medicine, kashan university of medical sciences, kashan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کاشان (Kashan university of medical sciences)

امیدرضا تمتاجی | omid reza tamtaji
research center for biochemistry and nutrition in metabolic diseases, kashan university of medical sciences, kashan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کاشان (Kashan university of medical sciences)

رسول مختاری | rasoul mokhtari
research center for biochemistry and nutrition in metabolic diseases, kashan university of medical sciences, kashan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کاشان (Kashan university of medical sciences)

سید علیرضا طلایی | sayyed alireza talaei
physiology research center, kashan university of medical sciences, kashan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کاشان (Kashan university of medical sciences)

نشانی اینترنتی http://wjps.ir/browse.php?a_code=A-10-163-2&slc_lang=en&sid=en
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