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Research in Pharmaceutical Sciences، جلد ۹، شماره ۶، صفحات ۴۸۹-۰
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عنوان انگلیسی Exon 3-deleted and full-length growth hormone receptor polymorphism frequencies in an Iranian population
چکیده انگلیسی مقاله The functional role of the exon 3 growth hormone receptor ( d3 GHR) polymorphism in human and its distributions in different populations is not clearly understood. The presence of full length growth hormone ( fl GHR) is the most important in metabolic risk factors. The aim of this study was to define the frequency distribution of d3 GHR/full-length GHR in an Iranian population. The presence of the d3 GHR polymorphism in healthy volunteers blood DNA (n=80, male=30 and female=50) was assessed by PCR using specific primers. The 935-bp and 592-bp fragments indicate the presence of the fl GHR and the exon3 deletion of GHR, respectively. The distribution of the GHR genotypes in this study were 31.4% (n=24) for fl/fl GHR, 49.7 % (n=41) for fl/d3 GHR, and 19.0 % ( n=15) for d3/d3 GHR. Frequencies of fl allele and d3 allele were 55.4% and 44.4% within whole population, respectively. There was no difference in allels frequencies of GHR in male ( fl =0.583, d3 =0.417) and female ( fl =0.540, d3 =0.460) when compared with whole population. The results showed that the frequency of d3/d3 GHR isoform was significantly lower than that of the fl / fl GHR and d3 / fl GHR. The frequencies of GHR polymorphisms were likely consistent with previous reports. Our finding is also consistant with Mexican population. The advantage of existence of the d3/d3 rather than fl/fl GHR polymorphisms in individuals and in correlation with diseases opens new insights for GH and insilin-like-growth factor-1 (IGF-I) axis .
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نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1600
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Short Communication
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