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Acta Medica Iranica، جلد ۵۶، شماره ۲، صفحات ۷۷-۸۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Comparison of Cytokine Expression in Multiple Sclerosis Patients and Healthy Volunteers
چکیده انگلیسی مقاله Multiple sclerosis (MS) is an autoimmune disease with the impaired balance of CD4 + T cells. This trial is a descriptive study to evaluate the expression of CD4 + T cell cytokines, interleukin (IL) ‑2, IL‑4, IL‑17, TGF‑β, and respectively related transcription factors, including T-bet, GATA3, RORγt and FoxP3 in MS patients. Sixteen relapsing-remitting MS (RRMS) patients receiving interferon beta (IFN-β)-1a in the stable phase of the disease and 14 healthy control volunteers (HCs) were enrolled in this study. The expression of cytokines and transcription factors was evaluated in peripheral blood mononuclear cells (PBMCs) of patients using real time PCR. The results of this study showed that the expression of IL-2 ( P ≤0.05), IL-4 ( P ≤0.05), IL-17 ( P ≤0.05) and RORγt ( P ≤0.01) in PBMCs of RRMS patients were significantly higher than those in HCs. The expression of TGF‑β, GATA3, and FoxP3 were higher but the RORγt expression was lower in the patients than HCs without reaching significant value. Observed results indicated differences in immune system cytokines of healthy volunteers and the patients that were in the stable phase and under immunomodulatory therapy especially in proinflammatory mediators. Therefore, any therapeutic strategy to restore the immune system balance is desirable in RRMS patients.
کلیدواژه‌های انگلیسی مقاله Multiple sclerosis,T cells,Cytokine,Transcription factor
نویسندگان مقاله عاتکه موسوی نسل خامنه | ateke mousavi nasl khameneh
department of immunology, school of public health, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

عباس میرشفیعی | abbas mirshafiey
department of neurology and ms research center, neuroscience institute, sina hospital, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

عبدالرضا ناصر مقدسی | abdorreza naser moghadasi
department of cellular and molecular nutrition, school of nutritional sciences and dietetics, international campus, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمدرضا شیری شاهسوار | mohammad reza shiri shahsavar
department of biostatistics, school of public health, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمدرضا اشراقیان | mohammad reza eshraghian
department of cellular and molecular nutrition, school of nutritional sciences and dietetics, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مریم shadanian | maryam shadanian
department of cellular and molecular nutrition, school of nutritional sciences and dietetics, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مینا عبدالهی | mina abdolahi
department of cellular and molecular nutrition, school of nutritional sciences and dietetics, international campus, tehran university of medical sciences, tehran, iran. and department of immunology, school of public health, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

علی اکبر صبور یراقی | ali akbar saboor yaraghi


نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/6298
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/56/article-56-571551.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Articles
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