این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Physiology and Pharmacology، جلد ۲۰، شماره ۳، صفحات ۱۴۷-۱۵۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Morphine-induced analgesic tolerance is associated with alteration of protein kinase Cγ and transient receptor potential vanilloid type 1 genes expression in rat lumbosacral cord and midbrain
چکیده انگلیسی مقاله Introduction: Transient receptor potential vanilloid type 1 (TRPV1) and protein kinase Cγ (PKCγ) are involved in sensitization/desensitization to noxious stimuli. We aimed to examine the gene expression levels of TRPV1 and PKCγ in rat lumbosacral cord and midbrain on days 1, 4 and 8 of induction of morphine analgesic tolerance. Methods: Two groups of male Wistar rats received twice daily saline (1 ml/kg) or morphine (10 mg/kg) for eight days and were monitored for analgesic tolerance with a hotplate test on days 1, 4 and 8 of the injections. Six independent groups in three sets were also treated with saline or morphine, decapitated on days 1, 4 or 8 of the schedule, respectively and their lumbosacral cord and midbrain were dissected. Results: The result of the hotplate test revealed induction of analgesic tolerance on days 4 and 8 of morphine injections. The TRPV1 gene expression in the lumbosacral cord was significantly increased only on day 4 of morphine injections, but the PKCγ gene expression remained with no significant changes on days 1, 4 and 8. In the midbrain, the TRPV1 gene expression was significantly increased only on day 1; however, the PKCγ gene expression was significantly increased on days 4 and 8 of morphine injections. Conclusion: It can be concluded that the TRPV1 gene expression changes in the lumbosacral cord and midbrain is associated with early phase of morphine-induced analgesic tolerance but the PKCγ gene expression is altered only in midbrain at the later phase of process.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله شمس الدین احمدی | shamseddin ahmadi
department of biological science and biotechnology, faculty of science, university of kurdistan, sanandaj, iran


ندا پروینی | neda parvini
department of biological science and biotechnology, faculty of science, university of kurdistan, sanandaj, iran
نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-916-1&slc_lang=en&sid=en
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Pain and addiction
نوع مقاله منتشر شده Original Research
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات