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Acta Medica Iranica، جلد ۵۵، شماره ۱۲، صفحات ۷۵۹-۷۶۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The Association Between Bisphenol A and Polycystic Ovarian Syndrome: A Case-Control Study
چکیده انگلیسی مقاله Polycystic ovarian syndrome (PCOS) is an endocrine metabolic disorder with unclear etiopathogenesis among reproductive age women. Evidences show genetic susceptibility and environmental factors were associated with PCOS. The aim of this study was to find the association between urinary concentrations of Bisphenol-A as an endocrine disrupting chemical (EDC) and PCOS. A case-control study was conducted in 51 samples in each group. All cases were selected from women who diagnosed with PCOS at Gynecology and infertility center. The control group was selected from women who had clinical file in the center due to previous problem and came for routine check-up and pap smear. The participants were asked to collect a first-morning urine sample before any medical interventions. Total BPA in urine were measured with High Performance Liquid Chromatography (HPLC) method. Comparison of BPA level between two groups shows significantly higher level in PCOS group compared with control group (3.34 ± 2.63 vs 1.43 ± 1.57 ng/mL, P-value < 0.001). Using logistic regression analysis, BPA as the main dependent variable, was significantly associated with PCOS with adjusted Odds Ratio (OR) equal to 1.53 (95% CI: 1.14-2.05, P-value =0.004). The results of this study indicated that BPA may play a major role in the PCOS pathogenesis. Further investigations with better design are necessary to confirm this association.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله بتول حسین رشیدی | batool hossein rashidi
department of medicinal chemistry, school of pharmacy, drug design and development research center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مسعود امانلو | massoud amanlou
department of obstetrics and gynecology, reproductive health research center, urmia university of medical sciences, urmia, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ارومیه (Urmia university of medical sciences)

طاهره بهروزی lak | tahere behrouzi lak
vali-e-asr reproductive health research center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محیا قاضی زاده | mahya ghazizadeh
vali-e-asr reproductive health research center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

فدیه حق اللهی | fedyeh haghollahi
department of reproductive health, school of nursing and mediwifery, tehran university of medical scinces, tehran, iran.

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

مریم باقری | maryam bagheri
breast diseases research center bdrc , tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

بیتا اسلامی | bita eslami


نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/6273
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/56/article-56-572185.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Articles
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