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Physiology and Pharmacology، جلد ۲۰، شماره ۳، صفحات ۱۹۷-۲۰۵
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عنوان انگلیسی Magnesium oxide nanoparticles reduce anxiety induced by morphine withdrawal in adult male mice
چکیده انگلیسی مقاله Introduction: Our previous study has showed that chronic administration of magnesium oxide nanoparticles (MgO NP) can reduce anxiety in adult male rat. In this study the effects of MgO NP on anxiety induced by morphine withdrawal were investigated in adult male mice. Methods: Adult male NMRI mice (weighing 27 ± 3 g) divided into groups: control, receiving intraperitoneal (i.p.) injection of MgO NP (1, 2.5, 5 mg/kg), morphine withdrawal groups that receiving saline or MgO NP (2.5, 5 &10 mg/kg) as acute (a single injection at the test day) and chronic (co-injected with morphine for 4 days). To develop morphine dependency, increasing doses of morphine (20, 40, 80 mg/kg( injected subcutaneously for 4 days. Mice received a final morphine injection (40 mg/kg) 3 hours prior to naloxone (5 mg/kg (i.p.) on the day of testing (day 4). In addicted groups, after naloxone injection, morphine withdrawal signs were evaluated. In all groups, anxiety like behavior was assessed by the elevated plus maze apparatus. Results: MgO NP (2.5 & 5 mg/kg) reduced anxiety like behavior (P< 0.05). Acute and chronic MgO NP injections (5&10 mg/kg) could significantly improve/alleviate anxiety like behavior (p< 0.05 & p< 0.01 respectively) and reduce locomotor activity (p< 0.05, acute; p< 0.05, & p< 0.01, chronic), rearing, climbing and weight loss in morphine withdrawn mice. Conclusion: Due to the positive effect of MgO NP on anxiety like behavior and morphine withdrawal signs and symptoms, this nanoparticle can be a potential candidate for reducing the side effects of chronic usage of morphine and morphine withdrawal.
کلیدواژه‌های انگلیسی مقاله Anxiety, Nanoparticles, Magnesium oxide, Morphine withdrawal
نویسندگان مقاله مهناز کسمتی | mahnaz kesmati
department of biology, faculty of science, shahid chamran university of ahvaz, ahvaz, iran

سازمان اصلی تایید شده: دانشگاه شهید چمران (Shahid chamran university)

مریم کونانی | maryam konani
department of biology, faculty of science, shahid chamran university of ahvaz, ahvaz, iran

سازمان اصلی تایید شده: دانشگاه شهید چمران (Shahid chamran university)

mozhhgan ترابی | mozhhgan torabi
department of biology, faculty of science, shahid chamran university of ahvaz, ahvaz, iran

سازمان اصلی تایید شده: دانشگاه شهید چمران (Shahid chamran university)

لطف اله خواجه پور | lotfollah khajehpour
department of biology, faculty of science, shahid chamran university of ahvaz, ahvaz, iran

سازمان اصلی تایید شده: دانشگاه شهید چمران (Shahid chamran university)

نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-879-1&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Nervous system (others)
نوع مقاله منتشر شده Original Research
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