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Physiology and Pharmacology، جلد ۲۰، شماره ۳، صفحات ۲۰۶-۲۱۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Sandifish (Holothuria scabra) ameliorates aging in menopausal women by increasing estradiol hormones
چکیده انگلیسی مقاله Introduction: Sandfish (Holothuria scabra) is a marine species generally sold as a raw material that has been dried even though the meat contains steroid hormone with high economic value, which has the potential to become a source of safe natural steroid hormone. This study was aimed to look at the potency of sandfish as an anti-aging for menopausal women. Sandfish could become a source of natural steroid for hormone replacement therapy to replace synthetic hormone that is proven to have negative impacts on health. Methods: This study used female rats (Rattus norvegicus) Sprague-Dawley Strain Variety II that were twelve weeks old and ovariectomized. In these animals, the bioassay test was conducted with the treatment of sandfish meat powder (SP) containing 30, 40, and 50 μg steroid/100 g. At the end of the treatment, the examination was carried out toward the concentration of steroid in blood serum using radioimmunoassay (RIA) and the uterine weight. Results: The treatment with SP in 30 μg steroid/100 g could increase the estradiol hormone in blood serum of test animals that were ovariectomized and produce the highest concentration of uterine weight. Conclusion: This study showed that a dose of SPcontaining 30 μg steroid/100 g body weight had the highest potential as an anti-aging in menopausal women.
کلیدواژه‌های انگلیسی مقاله Anti-aging, Menopause, Sandfish, Steroid
نویسندگان مقاله etty ریانی | etty riani
department of aquatic resources management, faculty of fishery and marine science, bogor agricultural university. jl. lingkar akademik, kampus ipb darmaga, bogor, west java, indonesia


chairunissa | chairunissa
faculty of veterinary medicine, bogor agricultural university, jl. agatis, kampus ipb darmaga, bogor, west java, indonesia


hera maheswari | hera maheswari
faculty of veterinary medicine, bogor agricultural university, jl. agatis, kampus ipb darmaga, bogor, west java, indonesia


محمد dzikrifishofa | muhammad dzikrifishofa
regional general hospital of leuwiliang, regency of bogor, cibeber i, leuwiliang, bogor, west java, indonesia


nastiti kusumorini | nastiti kusumorini
faculty of veterinary medicine, bogor agricultural university, jl. agatis, kampus ipb darmaga, bogor, west java, indonesia
نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-921-1&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Endocrinology
نوع مقاله منتشر شده Original Research
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