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Physiology and Pharmacology، جلد ۲۰، شماره ۲، صفحات ۱۱۷-۱۲۱
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عنوان انگلیسی Artemether effect and its interaction with vincristine and doxorubicin on human breast carcinoma MCF-7 cells
چکیده انگلیسی مقاله Introduction: For thousands of years, plants have been used as the main source of drug worldwide. Recently, it has been found out that the plant Artemisia annua and especially its derivatives such as artemether have anticancer properties. Methods: In this study, the anticancer effect of artemether on MCF-7 breast cancer cell line was examined. MTT assay was used to assess the viability of cancer cells. Results: The data showed that artemether (100-300 nM) resulted in MCF-7 growth inhibition. Artemether plus vincristine or doxorubicin compared to each drug alone showed significant cytotoxic effects. Over 50 percent of cells were killed in combination of non-effective doses of artemether and doxorubicin (50 and 160 nM, respectively). Conclusion: Taken together, the combined therapy of artemether and anticancer drugs would be a promising strategy for breast cancer but the effectiveness of such combination therapy needs to be verified by experimental and clinical investigations.
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نویسندگان مقاله محمد رسول سمندری bahraseman | mohammad rasoul samandari bahraseman
research department of biotechnology, institute of science and high technology and environmental sciences, graduateuniversity of advanced technology, kerman, iran


سولماز سرحدی | solmaz sarhadi
research department of biotechnology, institute of science and high technology and environmental sciences, graduateuniversity of advanced technology, kerman, iran


سعید اسماعیلی ماهانی | saeed esmaeili mahani
department of biology, faculty of sciences, shahid bahonar university of kerman

سازمان اصلی تایید شده: دانشگاه شهید باهنر (Shahid bahonar university)

نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-79-8&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Pharmacology
نوع مقاله منتشر شده Original Research
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