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Physiology and Pharmacology، جلد ۲۰، شماره ۱، صفحات ۳۸-۴۷
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عنوان انگلیسی Kisspeptin-13 ameliorates memory impairment induced by streptozotocin in male rats via cholinergic system
چکیده انگلیسی مقاله Introduction: Kisspeptin-13 (KP-13) is a novel endogenous factor, increases synaptic transmission and is involved in several behavioral functions such as anxiety, locomotion, epilepsy and avoidance learning. However, the role of this peptide on cognition has not been well clarified yet. Here we studied the effect of kisspeptin-13 pretreatment on spatial learning and also interaction with cholinergic and adrenergic systems. Methods: Eighty adult male Wistar rats were divided into 10 groups: saline + saline; saline + STZ; KP-13 + STZ; propranolol + STZ; prazosin + STZ; atropine + STZ; saline + KP-13 + STZ; propranolol + KP-13 + STZ; prazosin + KP-13 + STZ; atropine + KP-13+ STZ. Streptozotocin (STZ) (3mg/Kg) was administrated intracerebroventricularly (i.c.v), kisspeptin-13 was infused (1μg/2μl, i.c.v) 30 minutes before STZ and antagonists were infused (i.p) 30 minutes before kisspeptin-13. Memory performance was measured 14 days after STZ injection using Morris Water Maze (MWM) consisting of 4 blocks and one probe tests. Results: Pretreatment with kisspeptin-13 ameliorated acquisition (p = 0.001) and retrieval of memory impaired by STZ (P = 0.011). Moreover, we found that injection of atropine, but not propranolol or prazocin was able to reverse the memory enhancement caused by kisspeptin-13 (P = 0.037). Conclusion: Our findings indicate that facilitatory action of kisspeptin-13 on the spatial learning and memory in STZ-induced Alzheimer’s is mediated, at least in part, through cholinergic systems.
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نویسندگان مقاله مریم pourmir | maryam pourmir
guilan university of med sci

سازمان اصلی تایید شده: دانشگاه گیلان (Guilan university)

پروین بابایی | parvin babaei
guilan university of med sci

سازمان اصلی تایید شده: دانشگاه گیلان (Guilan university)

بهرام سلطانی تهرانی | bahram soltani tehrani
guilan university of med sci

سازمان اصلی تایید شده: دانشگاه گیلان (Guilan university)

نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-369-2&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Learning and memory
نوع مقاله منتشر شده Original Research
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