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Iranian Journal of Medical Sciences، جلد ۴۳، شماره ۲، صفحات ۰-۰
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عنوان انگلیسی The Preventive Role of Pioglitazone in Glycerol-Induced Acute Kidney Injury in Rats during Two Different Treatment Periods
چکیده انگلیسی مقاله Background: Acute kidney injury is the most life-threatening complication of rhabdomyolysis. Glycerol is commonly used to induce this injury. The aim was to investigate the renoprotective effects of pioglitazone and the possible advantage of administering the drug for a longer period. Methods: Twenty-four male Albino Wistar rats were randomly divided into 4 groups (n=6/group): (A) control, (B) glycerol (50%, 10 mL/kg intramuscularly), (C) glycerol+pioglitazone (10 mg/kg orally for 3 days), and (D) glycerol+pioglitazone (for 6 days). Serum urea and creatinine levels were measured to assess the renal function. Reduced glutathione (GSH) levels and histological alterations were also measured. Statistical analysis was performed using Prism (version 6). The numerical data were evaluated by ANOVA, followed by the Tukey tests. The categorical data were evaluated by the Mann–Whitney test and the Fisher exact tests. P< 0.05 were considered significant. Results: In the glycerol-injected rats, the serum urea and creatinine levels were increased (P< 0.001), while the GSH levels were decreased (P< 0.001) compared to Group A. The nephrotoxicity showed significant tubular (P=0.01) and glomerular (P=0.02) injuries. In the pioglitazone-treated rats, the changes in the serum biomarkers and in the GSH levels were reversed in Group C (P=0.01) and in Group D (P=0.01). The microscopic examinations of the kidneys also showed some improvement. No obvious statistically significant difference was found between these 2 preventive groups in most studied features. Conclusion: These results indicate that pioglitazone might have nephroprotective effects in this injury model. Pioglitazone succeeded in producing this effect within 3 days. Doubling the drug administration period did not produce any significant superior benefit.
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نویسندگان مقاله راما mousleh | rama mousleh
departmentof pharmacology and toxicology, faculty of pharmacy, damascus university, damascus, syria


shaza al laham | shaza al laham
departmentof oral histopathology, faculty of dentistry, damascus university, damascus, syria


احمد al manadili | ahmad al manadili


نشانی اینترنتی http://ijms.sums.ac.ir/index.php/IJMS/article/view/3434
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/147/article-147-574106.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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