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Acta Medica Iranica، جلد ۵۶، شماره ۳، صفحات ۱۵۱-۱۶۰
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عنوان انگلیسی Lithium Decreases Streptozocin-Induced Diabetic Neuropathy in Rats by Inhibiting of Adenosine Triphosphate (ATP) Degradation
چکیده انگلیسی مقاله One of the most frequent complications of diabetes is diabetic peripheral neuropathy. Hyperglycemia would result in the advancement of this condition over a period of time. The most effective way in preventing diabetic neuropathy is regular control of glucose. In this study; we evaluated the effects of lithium onstreptozocin (STZ)-induced diabetic neuropathy in rats. Diabetic neuropathy was created 7 weeks after administration of STZ (45 mg/kg). Lithium was added to drinking water (450 mg/l) for 7 weeks and its plasma level after this period of time was 0.17±0.02 mmol/l. Levels of adenosine triphosphate (ATP) in dorsal root ganglion (DRG) neurons, oxidative stress parameters, open-field activity test and morphological analysis were assessed in this investigation. Currentresults showed significant elevation of oxidative stress biomarkers, reduction of ATP, abnormal morphology of DRG neurons and decrease of total distance moved in rats with STZ-induced diabetic neuropathy. The alterations in mentioned parameters were considerably restored by lithium treatment. These findings provide evidence for protective effects of lithium on STZ-induced diabetic neuropathy.
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نویسندگان مقاله | Azar Aghazadeh Khasraghi
Department of Pharmacology and Toxicology, International Campus (TUMS-IC), School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.


| Maryam Baeeri
Department of Pharmacology and Toxicology, International Campus (TUMS-IC), School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.


| Borna Payandemehr
Department of Pharmacology and Toxicology, International Campus (TUMS-IC), School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.


| Mahshid Rezaeiroushan
Department of Pharmacology and Toxicology, International Campus (TUMS-IC), School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.


| Gelareh Vakilzadeh
Department of Pharmacology and Toxicology, International Campus (TUMS-IC), School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.


| Shokoufeh Hassani
Department of Pharmacology and Toxicology, International Campus (TUMS-IC), School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.


| Asieh Hosseini
Department of Pharmacology and Toxicology, International Campus (TUMS-IC), School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.


| Gholamreza Hassanzadeh
3Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.


| Ahmad Reza Dehpour
Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.


| Mohammad Sharifzadeh
Department of Pharmacology and Toxicology, International Campus (TUMS-IC), School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/6405
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/56/article-56-575567.pdf
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